Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. - Wikidata - awgldk - TriplyDB

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

http://www.wikidata.org/entity/Q34656871

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γ-Secretase inhibitors and modulators.REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials Radio electric asymmetric conveyer: a novel neuromodulation technology in Alzheimer's and other neurodegenerative diseases.Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery New treatment strategies for Alzheimer's disease: is there a hope?Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis Pharmacological targeting of the β-amyloid precursor protein intracellular domain.Modulation of inflammation in transgenic models of Alzheimer's disease Targeting microglia for the treatment of Alzheimer's disease.Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.Beyond immunotherapy: new approaches for disease modifying treatments for early Alzheimer's disease.A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer's Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis.Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice.Affinity of (nat/68)Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers.Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation Central and peripheral administration of antisense oligonucleotide targeting amyloid-β protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AβPPswe) mice.Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes.

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Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

http://www.wikidata.org/entity/Q34656871

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Multi-target action of the nov ...... term treatment in Tg2576 mice.

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Multi-target action of the nov ...... term treatment in Tg2576 mice.

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Multi-target action of the nov ...... term treatment in Tg2576 mice.

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Multi-target action of the nov ...... term treatment in Tg2576 mice.

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1471-2202-14-44

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BMC Neuroscience

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Multi-target action of the nov ...... term treatment in Tg2576 mice

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Arturo R Viscomi

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Gino Villetti

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Laura Calzà

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Luca Lorenzini

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Marco Gusciglio

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Maria Francesca Baroc

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Mercedes Fernandez

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Sandra Sivilia

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Simone Ottonello

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P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

Multi-target drugs: the trend of drug research and development

A specific amyloid-beta protein assembly in the brain impairs memory

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.

Alzheimer's disease: clinical trials and drug development.

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.

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1471-2202-14-44

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44

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10.1186/1471-2202-14-44

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14

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Alessandro Giuliani

Alessandro Giuliani

Vito Antonio Baldassarro

Vladimiro Pietrini

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2013-04-05T00:00:00Z

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236125703

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1015679981

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23560952

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Alzheimer's disease

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3626610

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