P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. - Wikidata - awgldk - TriplyDB

P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

http://www.wikidata.org/entity/Q34658181

about

The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells CD39 and CD161 modulate Th17 responses in Crohn's disease.Big opportunities for small molecules in immuno-oncology.Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells.P2X receptors: New players in cancer pain.P2X7 mRNA expression in non-small cell lung cancer: MicroRNA regulation and prognostic value.Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses.NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine.Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells.ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages.Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics Calcium Channels and Associated Receptors in Malignant Brain Tumor Therapy.Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in H9c2 cells.The role of microglial P2X7: modulation of cell death and cytokine release.Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death.Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells.PRAS40 signaling in tumor.Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor-Host Interaction and Therapeutic Perspectives.Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway.Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis.Hypermethylation downregulates P2X7 receptor expression in astrocytoma.The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?Novel high-throughput cell-based hybridoma screening methodology using the Celigo Image Cytometer.P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy.Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators.Potential implication of SGK1-dependent activity change in BV-2 microglial cells.The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways

P2860

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P2860

P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

http://www.wikidata.org/entity/Q34658181

description

2013 nî lūn-bûn

@nan

2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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type

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2X7 integrates PI3K/AKT and A ...... s to mediate tumor cell death.

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P2093

Aiping Bai

http://www.w3.org/2001/XMLSchema#string

Chunqing Zhang

http://www.w3.org/2001/XMLSchema#string

Keiichi Enjyoji

http://www.w3.org/2001/XMLSchema#string

Linglin Li

http://www.w3.org/2001/XMLSchema#string

Shu Bian

http://www.w3.org/2001/XMLSchema#string

Simon C Robson

http://www.w3.org/2001/XMLSchema#string

Wolfgang G Junger

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Xiaofeng Sun

http://www.w3.org/2001/XMLSchema#string

Yan Wu

http://www.w3.org/2001/XMLSchema#string

P2860

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

RanBPM associates with CD39 and modulates ecto-nucleotidase activity

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases

Autophagy modulation as a potential therapeutic target for diverse diseases

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

P2X receptors as cell-surface ATP sensors in health and disease

Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

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e60184

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