Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. - Wikidata - awgldk - TriplyDB

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

http://www.wikidata.org/entity/Q34658251

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Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic Approaches LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis Lithium suppresses AÎ² pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Alzheimer's Disease in Down Syndrome.Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila A nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression.Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction.Recent insights into the molecular genetics of dementia Current status on Alzheimer disease molecular genetics: from past, to present, to future.MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons.Understanding microRNAs in neurodegeneration.hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies Copy number variation in human health, disease, and evolution.The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients.Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans.Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins.Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes Cancer and neurodegenerative disorders: pathogenic convergence through microRNA regulation.Genetics of Vascular Dementia.Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes.Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder Monoallelic expression of the human FOXP2 speech gene.Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease.Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis Role of common and rare APP DNA sequence variants in Alzheimer disease Targeting protein aggregation for the treatment of degenerative diseases APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy.Down syndrome and Alzheimer's disease: Common pathways, common goals.Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.Molecular genetics of Alzheimer's disease: an update.

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Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

http://www.wikidata.org/entity/Q34658251

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2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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American Journal of Human Genetics

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Promoter mutations that increa ...... ciated with Alzheimer disease.

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Ellen Corsmit

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Peter P De Deyn

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Tim De Pooter

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Veerle Bogaerts

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P2860

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

VISTA: computational tools for comparative genomics

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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6

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78

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Christine Van Broeckhoven

Cornelia M. van Duijn

Kristel Sleegers

Nathalie Brouwers

Sebastiaan Engelborghs

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2006-04-10T00:00:00Z

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7094874

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16685645

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Alzheimer's disease

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1474091

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