WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
about
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeuticsThe ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling deviceKnockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells.Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.Crosstalk between kinases and Nedd4 family ubiquitin ligases.One Hippo and many masters: differential regulation of the Hippo pathway in cancer.Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes.WWOX, large common fragile site genes, and cancer.Repression of MicroRNA-372 by Arsenic Sulphide Inhibits Prostate Cancer Cell Proliferation and Migration through Regulation of large tumour suppressor kinase 2.Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.EGF Inhibits Wnt/β-Catenin-Induced Osteoblast Differentiation by Promoting β-Catenin Degradation.The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress.NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor.K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.Regulation of the Hippo Signaling Pathway by Ubiquitin Modification.Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma.High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer.Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer.
P2860
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P2860
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@ast
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@en
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@nl
type
label
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@ast
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@en
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@nl
prefLabel
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@ast
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@en
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@nl
P2093
P2860
P1433
P1476
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
@en
P2093
Benjamin Yeung
King-Ching Ho
Xiaolong Yang
P2860
P304
P356
10.1371/JOURNAL.PONE.0061027
P407
P577
2013-04-03T00:00:00Z