Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
about
Role of glycosphingolipids in the function of human serotonin₁A receptorsStructure and function of an irreversible agonist-β(2) adrenoceptor complexThe concept of allosteric interaction and its consequences for the chemistry of the brainNovel GPCR paradigms at the μ-opioid receptorComputational modeling of membrane proteinsPrinciples of allosteric interactions in cell signalingBiological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivityMembrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCRStabilized G protein binding site in the structure of constitutively active metarhodopsin-IIA transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.Opsin, a structural model for olfactory receptors?Nanobody stabilization of G protein-coupled receptor conformational states.A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-targetA unified view of "how allostery works"Molecular insights into the dynamics of pharmacogenetically important N-terminal variants of the human β2-adrenergic receptorA nontoxic pain killer designed by modeling of pathological receptor conformations.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Structure-function of the G protein-coupled receptor superfamily.Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorBiasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK.The structural basis of G-protein-coupled receptor signaling (Nobel Lecture)Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniquesAction of molecular switches in GPCRs--theoretical and experimental studies.The allosteric vestibule of a seven transmembrane helical receptor controls G-protein couplingFitting the complexity of GPCRs modulation into simple hypotheses of ligand design.A Pluridimensional View of Biased Agonism.Constitutively active CCR5 chemokine receptors differ in mediating HIV envelope-dependent fusion.Single-molecule force spectroscopy of G-protein-coupled receptors.Conformational selection and equilibrium governs the ability of retinals to bind opsin.Stabilization of G protein-coupled receptors by point mutations.Molecular docking screening using agonist-bound GPCR structures: probing the A2A adenosine receptor.Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activationBiased signaling: potential agonist and antagonist of PAR2.Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor
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P2860
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@ast
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@en
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@nl
type
label
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@ast
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@en
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@nl
prefLabel
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@ast
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@en
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@nl
P2860
P1433
P1476
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.
@en
P2860
P304
P356
10.1152/PHYSIOL.00002.2010
P577
2010-10-01T00:00:00Z