Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
about
Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantationStrategies to achieve conditional gene mutation in miceRAS oncogenes: weaving a tumorigenic webCombined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.BRAF kinase domain mutations are present in a subset of chronic myelomonocytic leukemia with wild-type RAS.NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemiaEVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cellsTargeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemiaPreclinical efficacy of MEK inhibition in Nras-mutant AML.Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic NrasDeficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesisPRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.Targeting oncogenic Ras signaling in hematologic malignancies.KRAS insertion mutations are oncogenic and exhibit distinct functional properties.Direct reprogramming by oncogenic Ras and Myc.Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progressionTiming of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.Activated N-Ras signaling regulates arterial-venous specification in zebrafishComparison of liver oncogenic potential among human RAS isoforms.Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functionsCancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiencyThe ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent.MEK1 is required for the development of NRAS-driven leukemia.Ecotropic viral integration site 1, stem cell self-renewal and leukemogenesis.An evolutionary perspective on chronic myelomonocytic leukemia.Translational hematology.Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.
P2860
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P2860
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@ast
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@en
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@nl
type
label
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@ast
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@en
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@nl
prefLabel
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@ast
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@en
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@nl
P2093
P2860
P1433
P1476
Hematopoiesis and leukemogenes ...... 12D from the endogenous locus.
@en
P2093
Andrew McDaniel
Benjamin S Braun
Emily Harding-Theobald
Jasmine C Y Wong
Keiko Akagi
Kevin M Haigis
Kevin Shannon
Linda Wolff
Scott C Kogan
P2860
P304
P356
10.1182/BLOOD-2010-04-280750
P407
P577
2010-12-16T00:00:00Z