Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell functionCommon variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMIPhysiologic characterization of type 2 diabetes-related lociLong-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular riskZinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantationDown-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretionGenome-wide association study identifies multiple loci associated with bladder cancer riskGenome-wide association studies in type 2 diabetesGenetic mapping in human diseaseBridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive PotentialIslet biology, the CDKN2A/B locus and type 2 diabetes risk.The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings.Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association dataIntegrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetesInteraction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.Zinc transporters and their role in the pancreatic β-cell.The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI.Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohortThe genetics of obesity: FTO leads the way.BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1Genetics of type 2 diabetes in European populations.Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.No detectable association of IGF2BP2 and SLC30A8 genes with type 2 diabetes in the population of Hyderabad, India.Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathyGenomics of heart failure.The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) studyThe emerging genetic architecture of type 2 diabetesHyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus fromHeterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions.Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.Novel genomic signals of recent selection in an Ethiopian population.Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans
P2860
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P2860
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Common variants of the novel t ...... pancreatic beta-cell function.
@ast
Common variants of the novel t ...... pancreatic beta-cell function.
@en
Common variants of the novel t ...... pancreatic beta-cell function.
@nl
type
label
Common variants of the novel t ...... pancreatic beta-cell function.
@ast
Common variants of the novel t ...... pancreatic beta-cell function.
@en
Common variants of the novel t ...... pancreatic beta-cell function.
@nl
prefLabel
Common variants of the novel t ...... pancreatic beta-cell function.
@ast
Common variants of the novel t ...... pancreatic beta-cell function.
@en
Common variants of the novel t ...... pancreatic beta-cell function.
@nl
P2093
P50
P356
P1433
P1476
Common variants of the novel t ...... pancreatic beta-cell function.
@en
P2093
Andrea Mari
Andrea Tura
Ele Ferrannini
Ibrahim M Ibrahim
Laura Pascoe
Mark Walker
RISC Consortium
U.K. Type 2 Diabetes Genetics Consortium
P304
P356
10.2337/DB07-0634
P407
P577
2007-09-05T00:00:00Z