Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
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Artemisinin: discovery from the Chinese herbal gardenTools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?Designing the next generation of medicines for malaria control and eradicationRecent advances in malaria drug discoveryUsing genetic methods to define the targets of compounds with antimalarial activityMalaria in South America: a drug discovery perspectiveMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetAntimalarial drug discovery - approaches and progress towards new medicines.A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malariaImaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryMathematical Modelling to Guide Drug Development for Malaria EliminationArtemisinin Action and Resistance in Plasmodium falciparumIntegrated dataset of screening hits against multiple neglected disease pathogensAgrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas diseaseAnticancer properties of distinct antimalarial drug classesEvaluation of antimalarial activity and toxicity of a new primaquine prodrugCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingOptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimensA novel multiple-stage antimalarial agent that inhibits protein synthesisIn vivo curative and protective potential of orally administered 5-aminolevulinic acid plus ferrous ion against malaria.Recent highlights in anti-protozoan drug development and resistance research.Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapyEx vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.Altered temporal response of malaria parasites determines differential sensitivity to artemisininThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesComparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivaxAntimalarial compounds in Phase II clinical development.Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery.The discovery of artemisinin and the Nobel Prize in Physiology or MedicineAntimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.Malaria biology and disease pathogenesis: insights for new treatments.Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.Modelling the time course of antimalarial parasite killing: a tour of animal and human models, translation and challengesDried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humansPharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.
P2860
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P2860
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@ast
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@en
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@nl
type
label
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@ast
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@en
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@nl
prefLabel
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@ast
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@en
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@nl
P2093
P2860
P50
P356
P1476
Synthetic ozonide drug candida ...... cure of uncomplicated malaria.
@en
P2093
Christian Scheurer
David M Shackleford
Francis C K Chiu
Heinrich Urwyler
Hugues Matile
Ian C Bathurst
J Carl Craft
Jonathan L Vennerstrom
Julia Morizzi
Kamaraj Sriraghavan
P2860
P304
P356
10.1073/PNAS.1015762108
P407
P577
2011-02-07T00:00:00Z