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Identification of an antimalarial synthetic trioxolane drug development candidateOpen Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesA long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaPreclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug CandidateNovel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse ModelInhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activitiesCPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activityThe activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasitesIsothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparumThiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparumCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingSocs2 and elf5 mediate prolactin-induced mammary gland developmentPassive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigenDiscovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for MalariaAminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.Novel orally active antimalarial thiazoles.Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity.Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivaxSynthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.Discovery of dual function acridones as a new antimalarial chemotype.The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humansIdentification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strainsIn vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium speciesBenzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials.Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.Arylmethylamino steroids as antiparasitic agents.Antiparasitic agents: new drugs on the horizon.
P50
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P50
name
Sergio Wittlin
@en
Sergio Wittlin
@nl
type
label
Sergio Wittlin
@en
Sergio Wittlin
@nl
prefLabel
Sergio Wittlin
@en
Sergio Wittlin
@nl