Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.
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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SETDirect evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTsHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseTherapeutic and diagnostic challenges for frontotemporal dementiaI1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2AHyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tauHirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.Mechanisms of tau-induced neurodegeneration.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer's pathology.Tau in Alzheimer disease and related tauopathies.Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorialDeveloping pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.Are tangles as toxic as they look?Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degenerationThe carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.Neuroprotection: lessons from hibernators.Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.Novel therapeutic strategies for the treatment of protein-misfolding diseases.The importance of tau phosphorylation for neurodegenerative diseasesAnesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.Tau aggregation in Alzheimer's disease: what role for phosphorylation?The role of tau in neurodegenerationDevelopmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assemblyTau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathiesDoes Alzheimer's disease begin in the brainstem?The role of tau in Alzheimer's disease and related disorders.Intracellular and extracellular tau.Mitochondrial dysfunction as a therapeutic target in progressive supranuclear palsy.Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.Recent rodent models for Alzheimer's disease: clinical implications and basic research.Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.Autophagy modulation for Alzheimer's disease therapy.
P2860
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P2860
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Polymerization of hyperphospho ...... nates its inhibitory activity.
@ast
Polymerization of hyperphospho ...... nates its inhibitory activity.
@en
Polymerization of hyperphospho ...... nates its inhibitory activity.
@nl
type
label
Polymerization of hyperphospho ...... nates its inhibitory activity.
@ast
Polymerization of hyperphospho ...... nates its inhibitory activity.
@en
Polymerization of hyperphospho ...... nates its inhibitory activity.
@nl
prefLabel
Polymerization of hyperphospho ...... nates its inhibitory activity.
@ast
Polymerization of hyperphospho ...... nates its inhibitory activity.
@en
Polymerization of hyperphospho ...... nates its inhibitory activity.
@nl
P2093
P2860
P356
P1476
Polymerization of hyperphospho ...... nates its inhibitory activity.
@en
P2093
Alejandra del C Alonso
Khalid Iqbal
P2860
P304
P356
10.1073/PNAS.0603214103
P407
P577
2006-05-30T00:00:00Z