Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes. - Wikidata - awgldk - TriplyDB

Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes.

Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes.

http://www.wikidata.org/entity/Q34702564

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Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity Gene expression variability in human hepatic drug metabolizing enzymes and transporters Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes.Berberis vulgaris extract/β-cyclodextrin complex increases protection of hepatic cells via suppression of apoptosis and lipogenesis pathways.Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening.Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma.GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.Biotransformations of Antidiabetic Vanadium Prodrugs in Mammalian Cells and Cell Culture Media: A XANES Spectroscopic Study.Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines.Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines.Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells - Effects on gene expression levels and thiopurine metabolism.Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems.Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human.Competency of different cell models to predict human hepatotoxic drugs.Differential impact of flavonoids on redox modulation, bioenergetics and cell signalling in normal and tumor cells: a comprehensive review.Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions.Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening.Evaluation of four human cell lines with distinct biotransformation properties for genotoxic screening.Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro.The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity.Commentary on prevention a possible drug-drug interaction: is concurrent administration of orlistat and pioglitazone increase the risk of durg-induced hepatotoxicity?Human cell line-dependent WC-Co nanoparticle cytotoxicity and genotoxicity: a key role of ROS production.Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.Sertraline induces endoplasmic reticulum stress in hepatic cells.A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.Mycotoxins' activity at toxic and sub-toxic concentrations: differential cytotoxic and genotoxic effects of single and combined administration of sterigmatocystin, ochratoxin A and citrinin on the hepatocellular cancer cell line Hep3B Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells.Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells.A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo.Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.Nevirapine induced mitochondrial dysfunction in HepG2 cells.

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P2860

Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes.

http://www.wikidata.org/entity/Q34702564

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2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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Similarities and differences i ...... and primary human hepatocytes.

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Similarities and differences i ...... and primary human hepatocytes.

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P2860

Revealing the architecture of gene regulation: the promise of eQTL studies

Transcription factors in liver development, differentiation, and regeneration

Mapping the genetic architecture of gene expression in human liver

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.

Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

Genetic basis of drug metabolism.

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.

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