Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
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Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosisHydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional SpecializationCorrelating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic TrapImatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategyAllosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.The role of dimer asymmetry and protomer dynamics in enzyme catalysis.Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanismConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src KinaseProtein dynamics and function from solution state NMR spectroscopy.Evolution and intelligent design in drug development.Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3).Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.Structural propensities of kinase family proteins from a Potts model of residue co-variation.Two-Dimensional NMR Lineshape Analysis.Discrimination between conformational selection and induced fit protein-ligand binding using Integrated Global Fit analysis.Conformational landscape and low lying excited states of imatinib.Drug targets evolve, and so should the methods.How and when does an anticancer drug leave its binding site?Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.Editorial: Function and Flexibility: Friend or Foe?Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.Label-free NMR-based dissociation kinetics determination.NMR line shape analysis of a multi-state ligand binding mechanism in chitosanase.Role of Molecular Interactions and Protein Rearrangement in the Dissociation Kinetics of p38α MAP Kinase Type-I/II/III Inhibitors.Acquired Resistance to Drugs Targeting Tyrosine Kinases.The multifaceted allosteric regulation of Aurora kinase A.Dynamics of human protein kinase Aurora A linked to drug selectivityMechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
P2860
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P2860
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@ast
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@en
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@nl
type
label
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@ast
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@en
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@nl
prefLabel
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@ast
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@en
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
@nl
P2093
P2860
P356
P1476
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases
@en
P2093
Dorothee Kern
Roman V Agafonov
Vanessa Buosi
P2860
P2888
P304
P356
10.1038/NSMB.2891
P577
2014-09-14T00:00:00Z