Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation
about
Advances in understanding chromosome silencing by the long non-coding RNA XistConsiderations when investigating lncRNA function in vivo.RNA-sequencing from single nuclei.The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.Xist regulation and function explored.Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells.Increased expression of the long noncoding RNA CRNDE-h indicates a poor prognosis in colorectal cancer, and is positively correlated with IRX5 mRNA expressionImpaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization.X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.Female mice lacking Xist RNA show partial dosage compensation and survive to termSHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells.A scaffold for X chromosome inactivation.Epigenesis and plasticity of mouse trophoblast stem cells.Mutation of the XIST gene upregulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos.Response to Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing".CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation.DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary.Spontaneous reactivation of clusters of X-linked genes is associated with the plasticity of X-inactivation in mouse trophoblast stem cells.LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms.
P2860
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P2860
Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation
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2011年の論文
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Disruption of a conserved regi ...... nted X chromosome inactivation
@ast
Disruption of a conserved regi ...... nted X chromosome inactivation
@en
Disruption of a conserved regi ...... nted X chromosome inactivation
@nl
type
label
Disruption of a conserved regi ...... nted X chromosome inactivation
@ast
Disruption of a conserved regi ...... nted X chromosome inactivation
@en
Disruption of a conserved regi ...... nted X chromosome inactivation
@nl
prefLabel
Disruption of a conserved regi ...... nted X chromosome inactivation
@ast
Disruption of a conserved regi ...... nted X chromosome inactivation
@en
Disruption of a conserved regi ...... nted X chromosome inactivation
@nl
P2093
P2860
P356
P1433
P1476
Disruption of a conserved regi ...... nted X chromosome inactivation
@en
P2093
Hamlata Dewchand
Jonathan Godwin
Neil Brockdorff
Sara Norton
Winifred Mak
P2860
P304
P356
10.1242/DEV.056812
P407
P577
2011-03-09T00:00:00Z