A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome - Wikidata - awgldk - TriplyDB

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

http://www.wikidata.org/entity/Q34709034

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Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations Wolfram Syndrome: Diagnosis, Management, and Treatment Modeling Kidney Disease with iPS Cells Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions.Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.Selective cognitive and psychiatric manifestations in Wolfram Syndrome.IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions Interactions between mitoNEET and NAF-1 in cells.Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1 Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.β Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.Pluripotent stem cells in disease modelling and drug discovery.A new era of disease modeling and drug discovery using induced pluripotent stem cells.Endoplasmic reticulum stress in beta cells and autoimmune diabetes.Calpain research for drug discovery: challenges and potential.Clinical utility gene card for: Wolfram syndrome.Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.Calpain-2 as a therapeutic target for acute neuronal injury.Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging.A novel heterozygous mutation of the WFS1 gene leading to constitutive endoplasmic reticulum stress is the cause of Wolfram syndrome.Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila.Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts.Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin.Wolfram syndrome: MAMs' connection?Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies.

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P2860

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

http://www.wikidata.org/entity/Q34709034

description

2014 nî lūn-bûn

@nan

2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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type

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

@nl

prefLabel

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

@ast

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

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PNAS.1421055111

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Proceedings of the National Academy of Sciences of the United States of America

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

@en

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Akihiro Umezawa

http://www.w3.org/2001/XMLSchema#string

Amber Neilson

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Bess A Marshall

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Christine M Oslowski

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Cris M Brown

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Fumihiko Urano

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Jana Mahadevan

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Kohsuke Kanekura

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Masashi Toyoda

http://www.w3.org/2001/XMLSchema#string

Mayu Yamazaki-Inoue

http://www.w3.org/2001/XMLSchema#string

P2860

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

m-Calpain is required for preimplantation embryonic development in mice.

Signal integration in the endoplasmic reticulum unfolded protein response

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

The calpain system

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49

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111

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Clay F. Semenkovich

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2014-11-24T00:00:00Z

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268874863

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25422446

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