Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality - Wikidata - awgldk - TriplyDB

Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality

Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality

http://www.wikidata.org/entity/Q34718631

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Molecular functions of thyroid hormones and their clinical significance in liver-related diseases Enzymatic intracrine regulation of white adipose tissue The brain and brown fat Adipose tissues and thyroid hormones Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.Deciphering direct and indirect influence of thyroid hormone with mouse genetics.Thyroid hormone regulation of metabolism The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.NT-PGC-1α activation attenuates high-fat diet-induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism Refeeding-induced brown adipose tissue glycogen hyper-accumulation in mice is mediated by insulin and catecholamines BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice.Selenium. Role of the essential metalloid in health Minireview: cracking the metabolic code for thyroid hormone signaling Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.Recent progress in the study of brown adipose tissue.Integration of body temperature into the analysis of energy expenditure in the mouse Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.Thyroid hormone signaling in energy homeostasis and energy metabolism.Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis--A Cohort Study in a Group of Thyroid Carcinoma Patients.Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice.Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis.Coordination of hypothalamic and pituitary T3 production regulates TSH expression.Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice.Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.The role of thyroid hormone and brown adipose tissue in energy homoeostasis The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.Type 2 deiodinase at the crossroads of thyroid hormone action

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Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality

http://www.wikidata.org/entity/Q34718631

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Disruption of thyroid hormone ...... tosis only at thermoneutrality

@ast

Disruption of thyroid hormone ...... tosis only at thermoneutrality

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Disruption of thyroid hormone ...... tosis only at thermoneutrality

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type

label

Disruption of thyroid hormone ...... tosis only at thermoneutrality

@ast

Disruption of thyroid hormone ...... tosis only at thermoneutrality

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Disruption of thyroid hormone ...... tosis only at thermoneutrality

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prefLabel

Disruption of thyroid hormone ...... tosis only at thermoneutrality

@ast

Disruption of thyroid hormone ...... tosis only at thermoneutrality

@en

Disruption of thyroid hormone ...... tosis only at thermoneutrality

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Disruption of thyroid hormone ...... tosis only at thermoneutrality

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Cintia Ueta

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David E Cohen

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Hye Won Kang

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Jessica A Hall

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Mayrin Correa-Medina

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Melany Castillo

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P2860

Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

A role for brown adipose tissue in diet-induced thermogenesis

Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

Unexpected evidence for active brown adipose tissue in adult humans

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis

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1082-1089

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10.2337/DB10-0758

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21335378

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