Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.
about
Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieuHeterologous expression of epothilone biosynthetic genes in Myxococcus xanthus.Tubulin-interactive natural products as anticancer agentsStabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Cancer wars: natural products strike backBrain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathiesEpothilones: From discovery to clinical trialsMitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells.Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cellsUnderstanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulationsPretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapyA novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathwayIxabepilone administered weekly or every three weeks in HER2-negative metastatic breast cancer patients; a randomized non-comparative phase II trialStabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded FormulationA natural love of natural products.A Phase II evaluation of ixabepilone (IND #59699, NSC #710428) in the treatment of recurrent or persistent leiomyosarcoma of the uterus: an NRG Oncology/Gynecologic Oncology Group StudyComparison of Epothilone and Taxol Binding in Yeast Tubulin using Molecular Modeling.Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolidesInhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complexOther paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma.Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.Development and validation of a rapid method for the detection of latrunculol A in plasma.Mechanisms of Taxol resistance related to microtubules.Fusarisetins: Structure-function studies on a novel class of cell migration inhibitorsIdentifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis.Enzymatic synthesis of epothilone A glycosidesLow dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Impact of vitrification on the meiotic spindle and components of the microtubule-organizing center in mouse mature oocytesMicrotubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolideProfile and potential of ixabepilone in the treatment of pancreatic cancerSubcellular distribution of epothilones in human tumor cells.Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering.The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cellsOptimizing ixabepilone treatment schedules in patients with advanced or metastatic breast cancer.Present and future evolution of advanced breast cancer therapy.Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone
P2860
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P2860
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Epothilones, a new class of mi ...... axol-like mechanism of action.
@ast
Epothilones, a new class of mi ...... axol-like mechanism of action.
@en
Epothilones, a new class of mi ...... axol-like mechanism of action.
@nl
type
label
Epothilones, a new class of mi ...... axol-like mechanism of action.
@ast
Epothilones, a new class of mi ...... axol-like mechanism of action.
@en
Epothilones, a new class of mi ...... axol-like mechanism of action.
@nl
prefLabel
Epothilones, a new class of mi ...... axol-like mechanism of action.
@ast
Epothilones, a new class of mi ...... axol-like mechanism of action.
@en
Epothilones, a new class of mi ...... axol-like mechanism of action.
@nl
P2093
P1433
P1476
Epothilones, a new class of mi ...... taxol-like mechanism of action
@en
P2093
Lazarides E
McQueney PA
P304
P407
P577
1995-06-01T00:00:00Z