Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus - Wikidata - awgldk - TriplyDB

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

http://www.wikidata.org/entity/Q34725095

about

Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin.Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases.In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.Response of Staphylococcus aureus to salicylate challenge.Gemifloxacin: a new fluoroquinolone approved for treatment of respiratory infections.Efflux-mediated antimicrobial resistance.Mechanisms of resistance to quinolones.Quinolone resistance due to reduced target enzyme expression Antistaphylococcal activity of WCK 771, a tricyclic fluoroquinolone, in animal infection models.Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus In vitro antibacterial resistance selection and quantitation.

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

http://www.wikidata.org/entity/Q34725095

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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label

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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prefLabel

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

@en

Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

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AAC.47.1.274-282.2003

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Antimicrobial Agents and Chemotherapy

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Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus

@en

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David C Hooper

http://www.w3.org/2001/XMLSchema#string

Dilek Ince

http://www.w3.org/2001/XMLSchema#string

L Christine Silver

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Xiamei Zhang

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P2860

DNA gyrase, topoisomerase IV, and the 4-quinolones

Antimicrobial activity and spectrum of LB20304, a novel fluoronaphthyridone

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

Structure and mechanism of DNA topoisomerase II

Crystal structure of the breakage-reunion domain of DNA gyrase

NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomes

Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.

Effects of mutations in GrlA of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity.

Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms.

Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci

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274-282

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scholarly article

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10.1128/AAC.47.1.274-282.2003

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10976470

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12499202

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149033

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