7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation - Wikidata - awgldk - TriplyDB

7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation

7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation

http://www.wikidata.org/entity/Q34735445

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The role of CRP and inflammation in the pathogenesis of age-related macular degeneration.Why AMD is a disease of ageing and not of development: mechanisms and insights.7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model.7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen.Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.Lipids, lipoproteins, and age-related macular degeneration Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes Oxidative stress, innate immunity, and age-related macular degeneration Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells.Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration.Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment.Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells.Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density.Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.Peroxynitrite-induced expression of inducible nitric oxide synthase and activated apoptosis via nuclear factor-kappa B pathway in retinal pigment epithelial cells and antagonism of cholecystokinin octapeptide-8 in vitro.Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway.The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics.Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols.Comparative cytotoxicity, oxidative stress, and cytokine secretion induced by two cyanotoxin variants, microcystin LR and RR, in human intestinal Caco-2 cells.Frontiers of Complex Disease Mechanisms: Membrane Surface Tension May Link Genotype to Phenotype in Glaucoma.

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P2860

7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation

http://www.wikidata.org/entity/Q34735445

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

7-ketocholesterol-induced infl ...... ctive oxygen species formation

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7-ketocholesterol-induced infl ...... ctive oxygen species formation

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Investigative Ophthalmology & Visual Science

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7-ketocholesterol-induced infl ...... ctive oxygen species formation

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Ignacio R Rodríguez

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Iranzu Pascual

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Jiahn-Dar Huang

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Jung Wha Lee

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P2860

NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

p38 MAP-kinases pathway regulation, function and role in human diseases

Regulation and function of NF-kappaB transcription factors in the immune system

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

Accumulation of cholesterol with age in human Bruch's membrane.

Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall.

Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations.

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation

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10.1167/IOVS.09-4854

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10

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51

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Ignacio M Larrayoz

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2010-06-16T00:00:00Z

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44679513

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7-oxocholesterol

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3066624

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