Complex relationship between Parkin mutations and Parkinson disease. - Wikidata - awgldk - TriplyDB

Complex relationship between Parkin mutations and Parkinson disease.

Complex relationship between Parkin mutations and Parkinson disease.

http://www.wikidata.org/entity/Q34737305

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Parkin mono-ubiquitinates Bcl-2 and regulates autophagy Dopamine covalently modifies and functionally inactivates parkin Genetics of Parkinson disease Parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)FlyBase portals to human disease research using Drosophila models Parkin-deficient mice are not a robust model of parkinsonism.Loss of locus coeruleus neurons and reduced startle in parkin null mice.The effects of oxidative stress on parkin and other E3 ligases.Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1-12 dosage.Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Risk of Parkinson disease in carriers of parkin mutations: estimation using the kin-cohort method.Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.How much phenotypic variation can be attributed to parkin genotype?Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Hypothesis: somatic mosaicism and Parkinson disease Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease Parkin mediates the degradation-independent ubiquitination of Hsp70 Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study.PINK1 mutation heterozygosity and the risk of Parkinson's disease.RNA knockdown as a potential therapeutic strategy in Parkinson's disease.Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria?Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease.Identifying the genetic components underlying the pathophysiology of movement disorders.Genetics of Parkinson disease.Progress in the pathogenesis and genetics of Parkinson's disease.A multidisciplinary study of patients with early-onset PD with and without parkin mutations.Parkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations Mitochondrial contribution to Parkinson's disease pathogenesis.Second mutation in PARK2 is absent in patients with sporadic Parkinson's disease and heterozygous exonic deletions/duplications in parkin gene.Twenty years since the discovery of the parkin gene.Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations.Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones.The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.MDPD: an integrated genetic information resource for Parkinson's disease.Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.Parkin gene alterations in ovarian carcinoma from northern Indian population.

P2860

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P2860

Complex relationship between Parkin mutations and Parkinson disease.

http://www.wikidata.org/entity/Q34737305

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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type

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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Complex relationship between Parkin mutations and Parkinson disease.

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American Journal of Medical Genetics Part A

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Complex relationship between Parkin mutations and Parkinson disease.

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P2093

Allan Levey

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Andrew West

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Christoph B Lücking

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David Nicholl

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Demetrius Maraganore

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Ebba Lohmann

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French Parkinson's Disease Gen ...... ibility on Parkinson's Disease

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Jean-François Deleuze

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Magali Periquet

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Matt Farrer

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584-591

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scholarly article

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10.1002/AJMG.10525

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5

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114

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John Anthony Hardy

Vincenzo Bonifati

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2002-07-01T00:00:00Z

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12116199

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Parkinson's disease