Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
about
Occlusion regulates epidermal cytokine production and inhibits scar formationMicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma.Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma.Epithelial regulation of mesenchymal tissue behavior.Up regulated expression of tumour necrosis factor {alpha} converting enzyme in peripheral monocytes of patients with early systemic sclerosisPersistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skinReduction of fibroblast size/mechanical force down-regulates TGF-β type II receptor: implications for human skin aging.Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.Update on pathophysiology of scleroderma with special reference to immunoinflammatory events.p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.Pulmonary Arterial Hypertension-A Deadly Complication of Systemic Sclerosis.Carcinoma-associated fibroblasts are a promising therapeutic target.Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer.Transforming growth factor beta as a therapeutic target in systemic sclerosis.Development of a provisional core set of response measures for clinical trials of systemic sclerosis.Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.The effect of TGF-β1 polymorphism on systemic sclerosis: a systematic review and pooled analysis of available literature.Update on etiopathogenesis of systemic sclerosis.Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha.MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression.Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta.The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells.Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms.CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma.Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling.Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma.YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts.
P2860
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P2860
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@ast
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@en
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@nl
type
label
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@ast
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@en
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@nl
prefLabel
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@ast
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@en
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@nl
P2860
P356
P1476
Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.
@en
P2093
John Varga
P2860
P304
P356
10.1002/ART.10413
P577
2002-07-01T00:00:00Z