Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease - Wikidata - awgldk - TriplyDB

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

http://www.wikidata.org/entity/Q28346591

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Smad7 is required for the development and function of the heart Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts Genetic and epigenetic regulation of intestinal fibrosis Mongersen, an oral Smad7 antisense oligonucleotide, in patients with active Crohn's disease Resolution of Inflammation: What Controls Its Onset?Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome Recent insights into the molecular pathogenesis of Crohn's disease: a review of emerging therapeutic targets Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases The Role of Neuropeptides in Mouse Models of Colitis Disrupted regulatory T cell homeostasis in inflammatory bowel diseases Nanomedicine and drug delivery strategies for treatment of inflammatory bowel disease Current stage in inflammatory bowel disease: What is next?Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation Balancing acts: the role of TGF-β in the mucosal immune system Targeting TGF-β signaling in cancer Identification and Characterization of a Novel Association between Dietary Potassium and Risk of Crohn's Disease and Ulcerative Colitis Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases.Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways TGF-β activation and function in immunity.Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling.Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.Smad3 signaling in the regenerating liver: implications for the regulation of IL-6 expression Synergy of Transforming Growth Factor Beta 1 and All Trans Retinoic Acid in the Treatment of Inflammatory Bowel Disease: Role of Regulatory T cells.Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.Molecular mechanisms by which casein glycomacropeptide maintains internal homeostasis in mice with experimental ulcerative colitis.Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation.Smad3 knock-out mice as a useful model to study intestinal fibrogenesis Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.Th17-related cytokines: new players in the control of chronic intestinal inflammation TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease.Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells.Antisense approach to inflammatory bowel disease: prospects and challenges.Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease Distinct profiles of effector cytokines mark the different phases of Crohn's disease Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.Immunoregulation in the gut: success and failures in human disease.Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis.

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P2860

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

http://www.wikidata.org/entity/Q28346591

description

2001 nî lūn-bûn

@nan

2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի օգոստոսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@ast

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@en

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@nl

type

label

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@ast

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@en

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@nl

prefLabel

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@ast

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@en

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

@nl

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Journal of Clinical Investigation

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Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

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A Kumberova

http://www.w3.org/2001/XMLSchema#string

C McKenzie

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G Monteleone

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H W Steer

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N M Croft

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T T MacDonald

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P2860

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

Regulation of immune responses by TGF-beta

Smads: transcriptional activators of TGF-beta responses

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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10.1172/JCI12821

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4

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11518734

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inflammatory bowel diseases

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