Large-scale chemical dissection of mitochondrial function - Wikidata - awgldk - TriplyDB

Large-scale chemical dissection of mitochondrial function

Large-scale chemical dissection of mitochondrial function

http://www.wikidata.org/entity/Q34754716

about

The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics Molecular aspects of thyroid hormone actions The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis Predicting new molecular targets for known drugs Is immunity a mechanism contributing to statin-induced diabetes?Mitochondrial targets for pharmacological intervention in human disease Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine Powering the immune system: mitochondria in immune function and deficiency Strategic applications of gene expression: from drug discovery/development to bedside Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology A Dormant Microbial Component in the Development of Preeclampsia Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity A chemical screen probing the relationship between mitochondrial content and cell size Differential mitochondrial toxicity screening and multi-parametric data analysis A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis Chemical approaches to nuclear receptors in metabolism Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic.Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice Estrogen: a master regulator of bioenergetic systems in the brain and body ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway.A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.Generalized theorems for nonlinear state space reconstruction.F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.Role of systems pharmacology in understanding drug adverse events.Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications.Detecting causality in complex ecosystems.Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease.Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.Screen for small molecules increasing the mitochondrial membrane potential.Functional genomic analysis of human mitochondrial RNA processing.A modern approach to the treatment of mitochondrial disease

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P2860

Large-scale chemical dissection of mitochondrial function

http://www.wikidata.org/entity/Q34754716

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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type

label

Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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prefLabel

Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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Large-scale chemical dissection of mitochondrial function

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P1433

Nature Biotechnology

P1476

Large-scale chemical dissection of mitochondrial function

@en

P2093

Arvind Ramanathan

http://www.w3.org/2001/XMLSchema#string

Bridget K Wagner

http://www.w3.org/2001/XMLSchema#string

David Peck

http://www.w3.org/2001/XMLSchema#string

Stuart L Schreiber

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Tamara J Gilbert

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Todd R Golub

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Toshimori Kitami

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Vamsi K Mootha

http://www.w3.org/2001/XMLSchema#string

P2860

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

Sequence and organization of the human mitochondrial genome

Functional discovery via a compendium of expression profiles.

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Myotonia precipitated by propranolol therapy

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mitochondria, oxidants, and aging

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Mitochondrial respiratory-chain diseases

Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism

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P304

343-351

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scholarly article

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10.1038/NBT1387

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3

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P478

26

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2008-02-24T00:00:00Z

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5555281

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18297058

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2715872

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