IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. - Wikidata - awgldk - TriplyDB

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

http://www.wikidata.org/entity/Q34755351

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CD2 promotes human natural killer cell membrane nanotube formation Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation Cell biological steps and checkpoints in accessing NK cell cytotoxicity Actin cytoskeletal defects in immunodeficiency Distinct Migration and Contact Dynamics of Resting and IL-2-Activated Human Natural Killer Cells.Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity Wiskott-Aldrich syndrome: a comprehensive review.Recurrent and Sustained Viral Infections in Primary Immunodeficiencies.Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia Autoimmunity in wiskott-Aldrich syndrome: an unsolved enigma.Actin engine in immunological synapse Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells.Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome.Insights into primary immune deficiency from quantitative microscopy.An Update on the Use of Immunomodulators in Primary Immunodeficiencies.NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity High- and Super-Resolution Microscopy Imaging of the NK Cell Immunological Synapse.Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells.Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment.Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control.Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells.Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.

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P2860

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

http://www.wikidata.org/entity/Q34755351

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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type

label

IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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prefLabel

IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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IL-2 induces a WAVE2-dependent ...... endent human NK cell function.

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Journal of Clinical Investigation

P1476

IL-2 induces a WAVE2-dependent ...... pendent human NK cell function

@en

P2093

Allison Paisley

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Gregory D Rak

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Linda Monaco-Shawver

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Pinaki P Banerjee

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Rahul Pandey

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Rushani Saltzman

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Sumita Roy-Ghanta

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P2860

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation.

The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse

Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity.

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading

Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses.

Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect.

Genotype-proteotype linkage in the Wiskott-Aldrich syndrome.

X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options.

A multiinstitutional survey of the Wiskott-Aldrich syndrome.

P304

1535-1548

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10.1172/JCI44862

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4

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121

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2011-03-07T00:00:00Z

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50304635

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21383498

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3069781

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