Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment.

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Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8 T Cell Survival, Differentiation, and Function

P2860

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Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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P1476

Mutations in PI3K110δ cause im ...... escued by rapamycin treatment.

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P2093

Alexander Vargas-Hernández

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Donna M Muzny

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Gulbu Uzel

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Ivan K Chinn

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James R Lupski

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Jordan S Orange

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Laura S Angelo

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Lisa R Forbes

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Luis M Allende

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Mohammed S Ehlayel

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P2860

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway

Syk regulation of phosphoinositide 3-kinase-dependent NK cell function

Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations.

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.

Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses.

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605-617.e7

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scholarly article

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10.1016/J.JACI.2017.11.042

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English

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P478

142

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P50

Raquel Ruiz-García

Emily M. Mace

P577

2018-01-09T00:00:00Z

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29330011

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P932

6109967

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Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment.

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P2860

P2860

Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment.

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type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932