Importance of each residue within secretin for receptor binding and biological activity
about
Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsLactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.Domain coupling in GPCRs: the engine for induced conformational changesSecond extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activationLigand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activityPredicting the effects of amino acid replacements in peptide hormones on their binding affinities for class B GPCRs and application to the design of secretin receptor antagonists.Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.Molecular basis of peptide activation of the GLP-1 receptor.The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor.Identification of key residues involved in adrenomedullin binding to the AM1 receptorA hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transductionReceptor oligomerization: from early evidence to current understanding in class B GPCRs.GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice.
P2860
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P2860
Importance of each residue within secretin for receptor binding and biological activity
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Importance of each residue within secretin for receptor binding and biological activity
@ast
Importance of each residue within secretin for receptor binding and biological activity
@en
Importance of each residue within secretin for receptor binding and biological activity
@nl
type
label
Importance of each residue within secretin for receptor binding and biological activity
@ast
Importance of each residue within secretin for receptor binding and biological activity
@en
Importance of each residue within secretin for receptor binding and biological activity
@nl
prefLabel
Importance of each residue within secretin for receptor binding and biological activity
@ast
Importance of each residue within secretin for receptor binding and biological activity
@en
Importance of each residue within secretin for receptor binding and biological activity
@nl
P2093
P2860
P356
P1433
P1476
Importance of each residue within secretin for receptor binding and biological activity
@en
P2093
Andrew J Bordner
Delia I Pinon
Jerez A Te
Laurence J Miller
Maoqing Dong
P2860
P304
P356
10.1021/BI200133U
P407
P577
2011-03-21T00:00:00Z