about
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffoldsEnantioselective alpha-trifluoromethylation of aldehydes via photoredox organocatalysisUnexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNASynthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified OligonucleotidesExhaustive Fluorine Scanning toward Potent p53-Mdm2 AntagonistsStructural basis for the enhanced stability of highly fluorinated proteinsCrystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding SiteOptimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacyFluorine in psychedelic phenethylaminesSynthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agentsSelective Pro-Apoptotic Activity of Novel 3,3'-(Aryl/Alkyl-Methylene)Bis(2-Hydroxynaphthalene-1,4-Dione) Derivatives on Human Cancer Cells via the Induction Reactive Oxygen SpeciesDifluoromethanesulfonyl hypervalent iodonium ylides for electrophilic difluoromethylthiolation reactions under copper catalysisHarnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue DrugsSynthetic biology approaches to fluorinated polyketidesCross-strand interactions of fluorinated amino acids in β-hairpin constructs.A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity In vivo.Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases.Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design.Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolinesSolution-phase synthesis of a diverse isocoumarin libraryMemory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease.Trisubstituted 2-trifluoromethyl pyrrolidines via catalytic asymmetric Michael addition/reductive cyclization.Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emissionLead optimization studies of cinnamic amide EP2 antagonistsMitochondrial-Targeted Molecular Imaging in Cardiac DiseaseHuprines as a new family of dual acting trypanocidal-antiplasmodial agentsFluorinated molecules in the diagnosis and treatment of neurodegenerative diseases.Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compoundsDesign, synthesis, and biological evaluation of novel fluorinated ethanolamines.Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights.An additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of ketones.Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.The [F]2-Fluoro-1,3-thiazolyl Moiety - an Easily-Accessible Structural Motif for Prospective Molecular Imaging Radiotracers.Photo-fluorodecarboxylation of 2-aryloxy and 2-aryl carboxylic acids.Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.Synthesis of a library of fluorescent 2-aryl-3-trifluoromethylnaphthofurans from naphthols by using a sequential pummerer-annulation/cross-coupling strategy and their photophysical properties.A convenient photocatalytic fluorination of unactivated C-H bonds.Natural and engineered biosynthesis of fluorinated natural products.Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis.Synthesis and anticancer activity evaluation of 3,4-mono- and bicyclosubstituted N-(het)aryl trifluoromethyl succinimides
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
The many roles for fluorine in medicinal chemistry.
@ast
The many roles for fluorine in medicinal chemistry.
@en
The many roles for fluorine in medicinal chemistry.
@nl
type
label
The many roles for fluorine in medicinal chemistry.
@ast
The many roles for fluorine in medicinal chemistry.
@en
The many roles for fluorine in medicinal chemistry.
@nl
prefLabel
The many roles for fluorine in medicinal chemistry.
@ast
The many roles for fluorine in medicinal chemistry.
@en
The many roles for fluorine in medicinal chemistry.
@nl
P356
P1476
The many roles for fluorine in medicinal chemistry.
@en
P2093
William K Hagmann
P304
P356
10.1021/JM800219F
P407
P577
2008-06-21T00:00:00Z