CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse - Wikidata - awgldk - TriplyDB

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

http://www.wikidata.org/entity/Q34792036

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The role of circulating fibrocytes in inflammation and autoimmunity Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells BAFF and rheumatic autoimmune disorders: implications for disease management and therapy BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin Molecular pathogenesis of skin fibrosis: insight from animal models.Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial.Scleroderma: from pathophysiology to novel therapeutic approaches.Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis.Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.CD19 as a molecular target in CNS autoimmunity.Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis The expression of TLR-9, CD86, and CD95 phenotypes in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy.Up regulated expression of tumour necrosis factor {alpha} converting enzyme in peripheral monocytes of patients with early systemic sclerosis Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency Systemic Sclerosis Patients Present Alterations in the Expression of Molecules Involved in B-Cell Regulation Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage Learning more from microarrays: insights from modules and networks.B cell reductive therapy in the treatment of autoimmune diseases: a focus on monoclonal antibody treatment of rheumatoid arthritis.Systemic and cell type-specific gene expression patterns in scleroderma skin.CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.Multiple paths to loss of anergy and gain of autoimmunity.B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis Collagen content in skin and internal organs of the tight skin mouse: an animal model of scleroderma A cellular viewpoint of anti-FVIII immune response in hemophilia A.Assessment of liver stiffness in patients with HCV and mixed cryoglobulinemia undergoing rituximab treatment.The role of B cells in systemic sclerosis.TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients.B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis.B lymphocytes: shedding new light on the pathogenesis of systemic sclerosis.Animal model of systemic sclerosis.Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma Animal models of systemic sclerosis: prospects and limitations.Biomarkers of scleroderma lung disease: recent progress.Scleroderma therapy: clinical overview of current trends and future perspective.B-lymphocyte signalling abnormalities and lupus immunopathology.

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CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

http://www.wikidata.org/entity/Q34792036

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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label

CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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prefLabel

CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

@ast

CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

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Journal of Clinical Investigation

P1476

CD19-dependent B lymphocyte si ...... munity in the tight-skin mouse

@en

P2093

Eriko Saito

http://www.w3.org/2001/XMLSchema#string

Kazuhiko Takehara

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Manabu Fujimoto

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Minoru Hasegawa

http://www.w3.org/2001/XMLSchema#string

Shinichi Sato

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Tetsuya Nagaoka

http://www.w3.org/2001/XMLSchema#string

Thomas F Tedder

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Yasuhito Hamaguchi

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Yuko Kaburagi

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P2860

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.

Rac1 mediates STAT3 activation by autocrine IL-6

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts

From T to B and back again: positive feedback in systemic autoimmune disease.

Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton

The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils.

P304

1453-1462

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scholarly article

P356

10.1172/JCI0215078

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10.1172/JCI15078

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P407

P433

11

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109

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Kazuhiro Komura

P577

2002-06-01T00:00:00Z

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12045259

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150999

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