Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
about
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerizationSpatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.Anchored FRET sensors detect local caspase activation prior to neuronal degenerationRescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Expression and activation of caspase-6 in human fetal and adult tissuesIdentification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseSox11 Reduces Caspase-6 Cleavage and Activity.Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.Caspase-6 activity predicts lower episodic memory ability in aged individualsCerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseIncreased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.Axon degeneration is key component of neuronal death in amyloid-β toxicity.Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.Genetics of Alzheimer's disease: an insight into presenilins and apolipoprotein E instigated neurodegeneration.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model
P2860
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P2860
Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Caspase-6 activation in famili ...... i or presenilin II mutations.
@ast
Caspase-6 activation in famili ...... i or presenilin II mutations.
@en
Caspase-6 activation in famili ...... i or presenilin II mutations.
@nl
type
label
Caspase-6 activation in famili ...... i or presenilin II mutations.
@ast
Caspase-6 activation in famili ...... i or presenilin II mutations.
@en
Caspase-6 activation in famili ...... i or presenilin II mutations.
@nl
prefLabel
Caspase-6 activation in famili ...... i or presenilin II mutations.
@ast
Caspase-6 activation in famili ...... i or presenilin II mutations.
@en
Caspase-6 activation in famili ...... i or presenilin II mutations.
@nl
P2093
P2860
P1476
Caspase-6 activation in famili ...... i or presenilin II mutations.
@en
P2093
Andréa C LeBlanc
Bernardino Ghetti
Nenad Bogdanovic
Steffen Albrecht
P2860
P304
P356
10.1097/NEN.0B013E3181C1DA10
P577
2009-12-01T00:00:00Z