Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
about
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapyLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseHerpes simplex virus interferes with amyloid precursor protein processingA γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APPNF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 productionLong-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in miceAn E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-proteinTargeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesisHeparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer diseaseNeuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease.Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.Expression of reticulon 3 in Alzheimer's disease brain.Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening.Search strategies used by APP transgenic mice during navigation in the Morris water maze.Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions.Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.Low-density lipoprotein receptor-related protein is decreased in optic neuropathy of Alzheimer diseaseModulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.Beta-secretase activity increases with aging in human, monkey, and mouse brain.Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's diseaseVPS35 haploinsufficiency increases Alzheimer's disease neuropathology.Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells.Clinical aspects of inflammation in Alzheimer's disease.GroEL-mediated protein folding: making the impossible, possible.Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statinsMaximizing the potential of plasma amyloid-beta as a diagnostic biomarker for Alzheimer's disease.Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's diseaseGamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain.The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease.Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology.A review on cholinesterase inhibitors for Alzheimer's disease.Neuroprotective effects of resveratrol in Alzheimer disease pathology.Helicobacter pylori and neurological diseases: Married by the laws of inflammation.
P2860
Q24604376-14873DCB-5743-4619-A446-2F48C09255C6Q24650450-57538FB1-6DF6-46D2-81DE-1177E3CC8801Q24810706-A5E33910-B295-4191-B9A8-88809F556752Q27314017-55C586DE-5F97-439B-9159-B5C9C9A34778Q28196676-5308D12E-F252-4AA5-B91B-1F5B6ABD9E01Q28539305-188EA029-5282-4BA1-AD46-657DB9451BAEQ28589972-0FA1D9EA-5364-41B5-97A7-AA776F8E431DQ28833244-96F3CFEC-F571-48CE-8F6F-44D2AD811FBAQ29976923-95870051-DEC9-45B0-AA7F-C35B1230BB33Q33847567-84E279C3-A028-4EAF-A551-4739B341392FQ33908201-01717546-3CC5-4681-8197-E17BBD3BBB3DQ33996719-C3540AA6-8B89-4627-B932-0E47430F13D7Q34092787-45EA07B6-EC7E-4321-9FA3-07976CC83026Q34141136-E7286F14-60B9-4160-9A3A-009C642B0221Q34340670-0B044392-39D5-4F79-966D-A33C2D29D8FDQ34489284-3DDA2496-7214-4C33-ADA6-295EB03A7EC2Q34651878-3A368F8F-E357-495E-869E-EE9E18BC721AQ34815754-9CF3EA37-046A-4674-AAE7-229FDA98858CQ35014671-E3B68424-9EE4-4CC8-8121-4D5FDB65F9E7Q35020981-5CF189CA-C26B-4148-B118-72D1986E79D8Q35023109-6F4C51A2-06FB-4195-8FDD-E62C9D515F32Q35083409-30C6F2B2-6FF5-4A88-B517-06A4B50D961AQ35085102-05D2F7C4-198C-4847-8A7E-1169FD098FAFQ35643397-A335D897-F739-43F2-83B9-5A98D93EE7B0Q35670733-604606BC-010E-4F4E-B9D3-5AAA86327380Q35915771-BF55EADC-DC86-46AC-8310-0C79EC2A9640Q36030499-4B0CAA8E-40E3-4AF9-9E6B-E88D4D7F2D2AQ36147173-9A887145-6649-4130-84EE-37C00492EC83Q36364213-6C1EA311-ED3F-4110-B5CD-F4DC696B7949Q36539816-A4E30F0E-B3ED-470C-A049-6E5F05C4A9E2Q36884234-2A83F06F-87A8-4468-957E-D6CEF3234DF1Q36919081-91D65AB1-6850-4E8D-B6A2-F2457888403BQ36988218-AE2CA46B-6F13-49C9-9C8E-C2E19483D6F3Q37232572-C8B75E93-9B95-4F50-A16D-A1DBB6B571ECQ37394529-237773C1-155B-49F5-8A0C-0A813C080280Q37690572-E5975F71-4357-4BCB-B4C4-AA3429248D1CQ37805574-5FE0F1AB-BA50-415B-95C6-D46B58F4D216Q38084168-A5E7CEAB-79FA-428E-BA44-48501BB81372Q38259550-DD09172F-8B6F-4AB7-8EBF-45D770D0A4CEQ38268664-C01E441B-BB4F-41B3-AD47-D2B2F413C95F
P2860
Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@ast
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@en
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@nl
type
label
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@ast
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@en
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@nl
prefLabel
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@ast
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@en
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@nl
P2860
P356
P1476
Deciphering the genesis and fa ...... erapies for Alzheimer disease.
@en
P2093
Dennis J Selkoe
P2860
P304
P356
10.1172/JCI0216783
P407
P577
2002-11-01T00:00:00Z