Novel substrates and functions for the ubiquitin-like molecule NEDD8.
about
The NEDD8 modification pathway in plantsRegulation of nucleolar signalling to p53 through NEDDylation of L11Posttranslational control of HuR functionCullin-RING ligases in regulation of autophagyMyeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modificationThe ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditionsStructural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitinationp73 as a pharmaceutical target for cancer therapyRegulation of parkin and PINK1 by neddylation.Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesisEndothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathwaysRegulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Targeting the neddylation pathway to suppress the growth of prostate cancer cells: therapeutic implication for the men's cancer.MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinomaThe essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signalingTargeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsCovalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin.Brap2 regulates temporal control of NF-κB localization mediated by inflammatory response.The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responsesHoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.Neddylation and deneddylation in cardiac biologyRegulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modificationsInduction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppressionSrc phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligaseThe neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.The nucleolus directly regulates p53 export and degradationPharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Uncovering ubiquitin and ubiquitin-like signaling networks.Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.Prediction of neddylation sites from protein sequences and sequence-derived properties.SCF E3 ubiquitin ligases as anticancer targets.An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic applicationSuppression of glioblastoma by targeting the overactivated protein neddylation pathway.
P2860
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P2860
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@ast
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@en
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@nl
type
label
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@ast
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@en
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@nl
prefLabel
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@ast
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@en
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@nl
P356
P1476
Novel substrates and functions for the ubiquitin-like molecule NEDD8.
@en
P2093
Dimitris P Xirodimas
P304
P356
10.1042/BST0360802
P577
2008-10-01T00:00:00Z