Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
about
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationDeletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaMechanics of T cell receptor gene rearrangementThe transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsThe timing of TCR alpha expression critically influences T cell development and selectionA mechanism misregulating p27 in tumors discovered in a functional genomic screen.Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.Loss of Gαi proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4+PD-1+CXCR5+/- T-cellsLineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cellsMEKK3 is essential for lymphopenia-induced T cell proliferation and survival.Progression of regulatory gene expression states in fetal and adult pro-T-cell development.Notch dimerization is required for leukemogenesis and T-cell development.Depletion of cytotoxic T-cells does not protect NUP98-HOXD13 mice from myelodysplastic syndrome but reveals a modest tumor immunosurveillance effect.Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulationImmature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombinationZfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.Bid is a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients.Notch Signaling in T-Cell Development and T-ALLhCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival.Protein kinase C and beyond.T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi.The RhoA transcriptional program in pre-T cells.Downregulation of the transcription factor KLF4 is required for the lineage commitment of T cells.Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytesHES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.A role for apoptosis-inducing factor in T cell development.Distinct roles for Syk and ZAP-70 during early thymocyte development.T-cell development, doing it in a dish.
P2860
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P2860
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@ast
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@en
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@nl
type
label
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@ast
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@en
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@nl
prefLabel
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@ast
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@en
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@nl
P1476
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
@en
P2093
Juan Carlos Zúñiga-Pflücker
P304
P356
10.1016/S1044-5323(02)00064-7
P577
2002-10-01T00:00:00Z