Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism - Wikidata - awgldk - TriplyDB

Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism

Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism

http://www.wikidata.org/entity/Q34839640

about

Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy Histone deacetylases as targets for treatment of multiple diseases Genetic and epigenetic factors influencing chronic kidney disease HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy.Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.Treatment of chronic kidney diseases with histone deacetylase inhibitors.β-hydroxybutyrate: much more than a metabolite Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro Recent developments in epigenetics of acute and chronic kidney diseases.Vorinostat protects against calcium oxalate-induced kidney injury in mice.Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury eNOS deficiency predisposes podocytes to injury in diabetes.Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function.HDAC inhibitors in experimental liver and kidney fibrosis.Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli.Histone deacetylase inhibitor enhances recovery after AKI.The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes.HDAC inhibitors in kidney development and disease.Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes.A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury.Gene regulation in the vascular endothelium: why epigenetics is important for the kidney.Diabetic nephropathy--emerging epigenetic mechanisms.Epigenetics of kidney disease.Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis.Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress‑induced apoptosis.Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.SAHA Suppresses Peritoneal Fibrosis in Mice.Greater efficacy of atorvastatin versus a non-statin lipid-lowering agent against renal injury: potential role as a histone deacetylase inhibitor.Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential.Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes.Therapeutic effects of histone deacetylase inhibitors on kidney disease.Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.Histone Deacetylase Inhibitors and Diabetic Kidney Disease HADC regulates the diabetic vascular endothelial dysfunction by targetting MnSOD

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Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism

http://www.wikidata.org/entity/Q34839640

description

2011 nî lūn-bûn

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The American Journal of Pathology

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Andrew Advani

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Darren A Yuen

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Darren J Kelly

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Kathryn E White

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Richard E Gilbert

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P2860

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Biochemistry and molecular cell biology of diabetic complications

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury

HDAC6 is a target for protection and regeneration following injury in the nervous system

10-year follow-up of intensive glucose control in type 2 diabetes

Anticancer activities of histone deacetylase inhibitors

Selection of internal reference genes for SYBR green qRT-PCR studies of rhesus monkey (Macaca mulatta) tissues.

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