HDAC6 is a target for protection and regeneration following injury in the nervous system
about
A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growthEpigenetic Regulation of Oxidative Stress in Ischemic StrokeWhat makes a RAG regeneration associated?Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS blockGrowing the growth cone: remodeling the cytoskeleton to promote axon regenerationEpigenetics of neural repair following spinal cord injuryA brief review of recent Charcot-Marie-Tooth research and prioritiesHDAC signaling in neuronal development and axon regenerationHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Developing epigenetic diagnostics and therapeutics for brain disordersHistone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regenerationGrowth control mechanisms in neuronal regenerationSelective toxicity by HDAC3 in neurons: regulation by Akt and GSK3betaProtein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cellsHistone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortexInhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic modelHistone deacetylase inhibitor pracinostat in doublet therapy: a unique strategy to improve therapeutic efficacy and to tackle herculean cancer chemoresistance.Effects of neonatal treatment with valproic acid on vasopressin immunoreactivity and olfactory behaviour in mice.Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's diseaseNeuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.Comparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families.Effects of αTAT1 and HDAC5 on axonal regeneration in adult neurons.Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin ASynthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agentsDysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylationHydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibitionA selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanismSAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease.The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosisHDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cellsEpigenetic mechanisms of neuroplasticity and the implications for stroke recovery.Targeting HDACs: a promising therapy for Alzheimer's disease.Expression of histone deacetylases in cellular compartments of the mouse brain and the effects of ischemia.Potential non-oncological applications of histone deacetylase inhibitors.
P2860
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P2860
HDAC6 is a target for protection and regeneration following injury in the nervous system
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
HDAC6 is a target for protection and regeneration following injury in the nervous system
@ast
HDAC6 is a target for protection and regeneration following injury in the nervous system
@en
HDAC6 is a target for protection and regeneration following injury in the nervous system
@nl
type
label
HDAC6 is a target for protection and regeneration following injury in the nervous system
@ast
HDAC6 is a target for protection and regeneration following injury in the nervous system
@en
HDAC6 is a target for protection and regeneration following injury in the nervous system
@nl
prefLabel
HDAC6 is a target for protection and regeneration following injury in the nervous system
@ast
HDAC6 is a target for protection and regeneration following injury in the nervous system
@en
HDAC6 is a target for protection and regeneration following injury in the nervous system
@nl
P2093
P2860
P3181
P356
P1476
HDAC6 is a target for protection and regeneration following injury in the nervous system
@en
P2093
Alan P Kozikowski
Ambreena Siddiq
Breset A Walker
Camille Brochier
Dianna E Willis
Jeffery L Twiss
Kathryn McLaughlin
Mark A Rivieccio
Melissa A D'Annibale
Rajiv R Ratan
P2860
P304
19599-19604
P3181
P356
10.1073/PNAS.0907935106
P407
P577
2009-11-02T00:00:00Z