Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. - Wikidata - awgldk - TriplyDB

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.

http://www.wikidata.org/entity/Q34854192

about

Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro Gleevec inhibits beta-amyloid production but not Notch cleavage Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease Golgi fragmentation in Alzheimer's disease Trafficking regulation of proteins in Alzheimer's disease Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease APP processing in Alzheimer's disease Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane β-amyloid triggers ALS-associated TDP-43 pathology in AD models Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Copper promotes the trafficking of the amyloid precursor protein Alzheimer disease models and human neuropathology: similarities and differences Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes A new functional screening system for identification of regulators for the generation of amyloid beta-protein.Characterization of an O-glycosylated plaque-associated protein from Alzheimer disease brain.Annexin II is required for apical transport in polarized epithelial cells.Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation.Amyloid and lipids in the pathology of Alzheimer disease.Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization The functions of the amyloid precursor protein gene.Beta-amyloid therapies in Alzheimer's disease.Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders Secretases as therapeutic targets for the treatment of Alzheimer's disease.Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's disease Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons Dysregulation of protein trafficking in neurodegeneration.Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins.Amyloid-β as a modulator of synaptic plasticity The amyloid beta ion channel hypothesis of Alzheimer's disease.

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P2860

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.

http://www.wikidata.org/entity/Q34854192

description

1999 nî lūn-bûn

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1999 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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Endoplasmic reticulum and tran ...... zheimer beta-amyloid peptides.

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Proceedings of the National Academy of Sciences of the United States of America

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Endoplasmic reticulum and tran ...... zheimer beta-amyloid peptides.

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P2093

B Hai

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F Checler

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G Thinakaran

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H Xu

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J P Greenfield

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J Tsai

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S S Sisodia

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P2860

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Dissection of Semliki Forest virus glycoprotein delivery from the trans-Golgi network to the cell surface in permeabilized BHK cells.

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

P304

742-747

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10.1073/PNAS.96.2.742

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2

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96

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Gunnar K. Gouras

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1999-01-01T00:00:00Z

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13395822

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9892704

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Alzheimer's disease

endoplasmic reticulum

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15207

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