Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. - Wikidata - awgldk - TriplyDB

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

http://www.wikidata.org/entity/Q34854518

about

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response Delayed Ras/PKA signaling augments the unfolded protein response Approaches to imaging unfolded secretory protein stress in living cells.Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata.A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.Phosphoregulation of Ire1 RNase splicing activity.Puf4 regulates both splicing and decay of HXL1 mRNA encoding the unfolded protein response transcription factor in Cryptococcus neoformans.The dynamic of the splicing of bZIP60 and the proteins encoded by the spliced and unspliced mRNAs reveals some unique features during the activation of UPR in Arabidopsis thaliana Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain.The unpredictability of prolonged activation of stress response pathways.Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.Endoplasmic reticulum stress sensing in the unfolded protein response A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.Endoplasmic reticulum (ER) stress response and its physiological roles in plants.Protein kinase and ribonuclease domains of IRE1 confer stress tolerance, vegetative growth, and reproductive development in Arabidopsis.Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association Proteostasis control by the unfolded protein response The eukaryotic protein kinase superfamily of the necrotrophic fungal plant pathogen, Sclerotinia sclerotiorum.Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1.Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD.Expression control of the AMPK regulatory subunit and its functional significance in yeast ER stress response.Unfolded protein responses with or without unfolded proteins?Erratum: Proteostasis control by the unfolded protein response.The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance.Putting the brakes on the unfolded protein response.Crosstalk between the unfolded protein response and pathways that regulate pathogenic development in Ustilago maydis.BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response.AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts.Nuclear mRNA degradation tunes the gain of the unfolded protein response in Saccharomyces cerevisiae.

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P2860

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

http://www.wikidata.org/entity/Q34854518

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@ast

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@en

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@nl

type

label

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@ast

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@en

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@nl

prefLabel

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@ast

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@en

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@nl

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Journal of Cell Biology

P1476

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase.

@en

P2093

Aditi Chawla

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Gourisankar Ghosh

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Maho Niwa

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Sutapa Chakrabarti

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P2860

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

Signal integration in the endoplasmic reticulum unfolded protein response

The conformational plasticity of protein kinases

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus.

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins.

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response.

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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41-50

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10.1083/JCB.201008071

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1

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193

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50891772

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21444691

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3082189

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