KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
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Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activityEpigenomics of leukemia: from mechanisms to therapeutic applicationsMechanisms of epigenetic regulation of leukemia onset and progressionHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionChromatin dynamics during cellular reprogrammingLinking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylasesPlant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone DemethylasesKDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and WomenCo-regulation of histone-modifying enzymes in cancerTargeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.Chromatin proteins and modifications as drug targets.Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.Chromatin and oxygen sensing in the context of JmjC histone demethylasesA developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathwayKDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapyFbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemiaHistone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.Reactive oxygen species in eradicating acute myeloid leukemic stem cellsEpigenetic changes: a common theme in acute myelogenous leukemogenesisEpigenetic reprogramming in cancer.Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes.RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenasesRoles of histone methyl-modifying enzymes in development and progression of cancer.Histone lysine demethylases as targets for anticancer therapy.The roles of Jumonji-type oxygenases in human disease.Chromatin modifiers and the promise of epigenetic therapy in acute leukemiaTargeting the histone orthography of cancer: drugs for writers, erasers and readers.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Post-translational control of transcription factors: methylation ranks highly.
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P2860
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@ast
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@en
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@nl
type
label
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@ast
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@en
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@nl
prefLabel
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@ast
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@en
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@nl
P2860
P1433
P1476
KDM2b/JHDM1b, an H3K36me2-spec ...... ance of acute myeloid leukemia
@en
P2093
Anh Tram Nguyen
P2860
P304
P356
10.1182/BLOOD-2010-10-312736
P407
P50
P577
2011-02-10T00:00:00Z