AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. - Wikidata - awgldk - TriplyDB

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

http://www.wikidata.org/entity/Q34918857

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Histone methyltransferases: novel targets for tumor and developmental defects Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Epigenetics in Cancer: A Hematological Perspective Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.The molecular mechanics of mixed lineage leukemia.DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Molecular mechanisms of MLL-associated leukemia.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Inhibitors of protein methyltransferases as chemical tools.The upstreams and downstreams of H3K79 methylation by DOT1L.Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia Cancer epigenetics: Reading the future of leukaemia.Accumulation of long-term transcriptionally active integrated retroviral vectors in active promoters and enhancers.Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.A Role for Mono-methylation of Histone H3-K27 in Gene Activity in Drosophila.LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.

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P2860

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

http://www.wikidata.org/entity/Q34918857

description

2014 nî lūn-bûn

@nan

2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@ast

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@en

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@nl

type

label

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@ast

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@en

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@nl

prefLabel

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@ast

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@en

AF10 regulates progressive H3K ...... ssion in diverse AML subtypes.

@nl

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P356

J.CCELL.2014.10.009

P1433

P1476

AF10 regulates progressive H3K ...... ession in diverse AML subtypes

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P2093

Ali Cihan

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Amit U Sinha

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Anagha Deshpande

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Aniruddha J Deshpande

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Chun-Wei Chen

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Deepti Banka

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Gloria Ibáñez

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James E Bradner

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Jenny Chang

http://www.w3.org/2001/XMLSchema#string

Liuda Dzhekieva

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P2860

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Chromatin modifications and their function

Characterization of the DOT1L network: implications of diverse roles for DOT1L

Misguided transcriptional elongation causes mixed lineage leukemia

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scholarly article

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10.1016/J.CCELL.2014.10.009

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6

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26

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Kathrin M. Bernt

Andrei Krivtsov

Kathrin M Bernt

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2014-11-20T00:00:00Z

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25464900

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4291116

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