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The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and OpportunitiesCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaSelective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons.AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.Chromatin-modifying enzymes as modulators of reprogrammingEzh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic LeukemiaMLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemiaTransient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy.Leukemia stem cells and human acute lymphoblastic leukemia.Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.Epigenetic modifiers in normal and malignant hematopoiesis.Histone profiles in cancer.Eradication of CD19+ leukemia by targeted calicheamicin θ.A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells.A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases.The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors.Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs.HDAC expression patterns in pediatric ALL.Assessment of a combined, adenovirus-mediated oncolytic and immunostimulatory tumor therapy.A role for DOT1L inMLL-rearranged leukemiasHuman Milk and the Response of Intestinal Epithelium to Infection
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description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Kathrin M. Bernt
@ast
Kathrin M. Bernt
@en
Kathrin M. Bernt
@es
Kathrin M. Bernt
@nl
Kathrin M. Bernt
@sl
type
label
Kathrin M. Bernt
@ast
Kathrin M. Bernt
@en
Kathrin M. Bernt
@es
Kathrin M. Bernt
@nl
Kathrin M. Bernt
@sl
prefLabel
Kathrin M. Bernt
@ast
Kathrin M. Bernt
@en
Kathrin M. Bernt
@es
Kathrin M. Bernt
@nl
Kathrin M. Bernt
@sl
P1053
L-1826-2016
P106
P1153
6602306534
P21
P31
P3829
P496
0000-0002-5400-0482