Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. - Wikidata - awgldk - TriplyDB

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.

http://www.wikidata.org/entity/Q34955481

about

Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits Cell biology of spinocerebellar ataxia Integration of modeling with experimental and clinical findings synthesizes and refines the central role of inositol 1,4,5-trisphosphate receptor 1 in spinocerebellar ataxia The unstable repeats--three evolving faces of neurological disease Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes Protein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1 Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep.Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.A cellular system that degrades misfolded proteins and protects against neurodegeneration Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disorders Polyglutamine (polyQ) disorders: the chromatin connection.Epigenetic mechanisms governing the process of neurodegeneration.Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3.Epigenetics in nucleotide repeat expansion disorders.Acetyltransferases (HATs) as targets for neurological therapeutics Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias.SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities.Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.A HAT for sleep?: epigenetic regulation of sleep by Tip60 in Drosophila.Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.Polyglutamine spinocerebellar ataxias - from genes to potential treatments.Epigenetic profiles in polyglutamine disorders.

P2860

Q26748876-A15A71F4-7BE0-44E9-BB36-9EFA759FCCEE Q26829511-626220A5-1AD8-4EFE-9F62-9517B9705D5D Q26864714-893B3140-2820-4744-A273-1272536A1B73 Q27025923-59EDFB9D-BFFC-481E-A561-42DC36386567 Q27308947-A6D8AF2F-B954-438F-9A92-AED5E4F4D7AA Q27680453-D96404A5-AEE2-438B-BB84-54B32D4CDBCA Q30422849-8AC8F61E-544C-4EDC-AF96-7EB774B45A86 Q30528879-A0C97F27-0F72-420F-BA7A-0A884C90023D Q35175402-41D549FA-E306-4270-8321-E06AE475064E Q35653318-17444619-FEE4-4DE6-A249-20B8BC6DB1FB Q35959200-6C4B24A9-7834-4351-8337-60E5F2FA47D2 Q36328114-2253A350-7E38-4F1E-969A-93537D3FAE1B Q36405886-01855974-148C-4162-9A1E-A6AF13EFEDD7 Q36436774-7D8D5E71-0A51-430E-BC8D-38CB0D3B51BF Q36848454-3AC98154-FEA0-4D5E-8329-F7DAADCDB092 Q37249167-49163A04-D005-4FE2-88D0-4157EF233196 Q37619548-936FB67C-4B03-4AB0-9321-78D8F9C47A94 Q37910368-CD5D1273-F3DE-438B-B413-77812ED2CFF3 Q38005302-C5D6606A-7D38-4FDF-A6FB-0F5426BB3921 Q38094663-27D7C91D-69CC-4F61-B0ED-A7F6B0EFA552 Q39103483-291966D2-DE72-4BAD-A276-0CF5BFAFBE09 Q39552099-261F95B7-C090-4172-9DA5-8D5F35E9E6EC Q40003551-E6BD2606-7B45-4A6B-AEA7-D90D1932732E Q41914545-1554A5B5-B90B-42F3-BA60-98F558E8AA2D Q43092408-E120433C-CDAE-4B02-A8AD-56C0B9EF50DF Q47880472-33EB739C-4C52-440D-BA90-8A1BA282FFC0 Q49668183-A6FCD28C-1486-481B-B072-AD2D2DCA5098

P2860

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.

http://www.wikidata.org/entity/Q34955481

description

2011 nî lūn-bûn

@nan

2011 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մարտին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@ast

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@en

Partial loss of Tip60 slows mi ...... spinocerebellar ataxia type 1

@nl

type

label

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@ast

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@en

Partial loss of Tip60 slows mi ...... spinocerebellar ataxia type 1

@nl

prefLabel

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@ast

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@en

Partial loss of Tip60 slows mi ...... spinocerebellar ataxia type 1

@nl

P1433

Q34955481-0AD63ECF-9D33-472F-9034-7588CB0CB806

P1476

Q34955481-05A32EFA-C455-4306-8E5F-4660AB5B5476

P2093

Q34955481-048C80F9-5FBB-4E21-A870-D8CE5EED9BCD

Q34955481-126BE022-44E8-48E2-BEE7-53A41EE31123

Q34955481-406EA174-E66F-4F5A-894C-40A913C11D6C

Q34955481-AA13364B-FD42-4402-A05B-C3B02C183EE2

P2860

Q34955481-07BB0642-ABCC-45DF-BFFA-74E17C056E40

Q34955481-082D99D3-F430-45D3-9E18-698226C97011

Q34955481-0AA1AB84-2190-4C4F-B19B-78C062B83EDD

Q34955481-1BAEB8F8-6C16-46A2-8B18-63AE534087C5

Q34955481-2203E7DB-1A45-461E-85D5-1167293123EB

Q34955481-24E03DED-B2D4-41BB-9E47-F3067BFD6EC0

Q34955481-30E9BD82-A176-4EB0-8AB3-66269A11691F

Q34955481-3A839223-0595-4BFD-A6C2-24E03C71B2C8

Q34955481-3D5CEC31-3504-4C1F-905F-E33524005FE0

Q34955481-470DB056-8BF1-4DDB-A6A9-D9471FC6E44E

P304

Q34955481-101DDF74-BAF7-44C2-A04E-E57DC33B9B6F

P31

Q34955481-9432F093-19D7-4CA2-A435-6F832C13523B

P356

Q34955481-DEEDFF48-8EB9-4DBA-B3F2-62E5B9703533

P433

Q34955481-E25EF6AF-29BA-4503-9FB8-E2D4D6DF33B8

P478

Q34955481-452565AD-F199-438F-A750-0F04B71BAC49

P50

Q34955481-11351604-9A12-4DCF-B9CB-1683D8F5CB89

Q34955481-A58DE316-DB50-4B86-A55D-9D1E0E891FD7

P577

Q34955481-45A06EB6-EEDB-470A-B19B-D95157FC52CE

P5875

Q34955481-DF5267B8-9C21-46B1-A47A-9B714D7D0941

P698

Q34955481-C14BFA55-CBB6-4BD2-AC7D-0C45D50EE90F

P932

Q34955481-B29DF51D-DFAF-4BB9-B7AF-181ADF3D3877

P356

P1433

Human Molecular Genetics

P1476

Partial loss of Tip60 slows mi ...... xia type 1 (SCA1) mouse model.

@en

P2093

J Michael Andresen

http://www.w3.org/2001/XMLSchema#string

John Lough

http://www.w3.org/2001/XMLSchema#string

Kristin M Gehrking

http://www.w3.org/2001/XMLSchema#string

Lisa Duvick

http://www.w3.org/2001/XMLSchema#string

P2860

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

Identification of a self-association region within the SCA1 gene product, ataxin-1

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

RNA association and nucleocytoplasmic shuttling by ataxin-1

Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.

The structure of the AXH domain of spinocerebellar ataxin-1

Tip60 is a nuclear hormone receptor coactivator

Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins

P304

2204-2212

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDR108

http://www.w3.org/2001/XMLSchema#string

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

20

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-03-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

50808196

http://www.w3.org/2001/XMLSchema#string

P698

21427130

http://www.w3.org/2001/XMLSchema#string

P932

3090197

http://www.w3.org/2001/XMLSchema#string