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Cholangiocarcinoma: molecular pathways and therapeutic opportunities

Cholangiocarcinoma: molecular pathways and therapeutic opportunities

http://www.wikidata.org/entity/Q34959174

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Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation Molecular profiling of biliary tract cancer: a target rich disease The rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine?Targeted therapy in biliary tract cancers-current limitations and potentials in the future.L1 Cell Adhesion Molecule Promotes Migration and Invasion via JNK Activation in Extrahepatic Cholangiocarcinoma Cells with Activating KRAS Mutation.MiR-199a-3p enhances cisplatin sensitivity of cholangiocarcinoma cells by inhibiting mTOR signaling pathway and expression of MDR1 Generation, characterization and preclinical studies of a human anti-L1CAM monoclonal antibody that cross-reacts with rodent L1CAM Pathological characteristics of intraductal polypoid neoplasms of bile ducts in Thailand.Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area.Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management.Combination of anti-L1 cell adhesion molecule antibody and gemcitabine or cisplatin improves the therapeutic response of intrahepatic cholangiocarcinoma Molecular genetics and targeted therapeutics in biliary tract carcinoma.Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.Malignancies in Primary Sclerosing Cholangitis--A Continuing Threat Overexpression of ZNF703 facilitates tumorigenesis and predicts unfavorable prognosis in patients with cholangiocarcinoma.Serum and tissue markers in hepatocellular carcinoma and cholangiocarcinoma: clinical and prognostic implications Human liver myofibroblasts during development and diseases with a focus on portal (myo)fibroblasts.High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy.Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).Intrahepatic cholangiocarcinoma: current management and emerging therapies.Emerging molecular therapeutic targets for cholangiocarcinoma.Liver capsule: Cholangiocarcinoma (CCA).Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignancies.Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma.LncRNA AFAP1-AS1 promotes growth and metastasis of cholangiocarcinoma cells.Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma.Long non-coding RNA UCA1 indicates an unfavorable prognosis and promotes tumorigenesis via regulating AKT/GSK-3β signaling pathway in cholangiocarcinoma.Impact of Secreted Protein Acidic and Rich in Cysteine (SPARC) Expression on Prognosis After Surgical Resection for Biliary Carcinoma.Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.Overexpression of periostin and distinct mesothelin forms predict malignant progression in a rat cholangiocarcinoma model.Targeting cholangiocarcinoma.Tumor necrosis and infiltrating macrophages predict survival after curative resection for cholangiocarcinoma.Prognostic Significance of Tumor Necrosis in Hilar Cholangiocarcinoma.Solamargine derived from Solanum nigrum induces apoptosis of human cholangiocarcinoma QBC939 cells.Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma

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Cholangiocarcinoma: molecular pathways and therapeutic opportunities

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014年の論文

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Cholangiocarcinoma: molecular pathways and therapeutic opportunities

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Cholangiocarcinoma: molecular pathways and therapeutic opportunities

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Seminars in Liver Disease

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Cholangiocarcinoma: molecular pathways and therapeutic opportunities

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Mitesh J Borad

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Sumera Rizvi

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Tushar Patel

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P2860

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

Cholangiocarcinoma

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

Genetic profiling of intrahepatic cholangiocarcinoma

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Identification of targetable FGFR gene fusions in diverse cancers.

Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

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34

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Gregory J Gores

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25369307

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cholangiocarcinoma

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