Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence - Wikidata - awgldk - TriplyDB

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence

http://www.wikidata.org/entity/Q34960856

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Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells Redefining the viral reservoirs that prevent HIV-1 eradication Animal models in HIV cure research New assays for monitoring residual HIV burden in effectively treated individuals HIV-1 eradication strategies: design and assessment The immunological synapse: the gateway to the HIV reservoir Persistence of viral reservoirs in multiple tissues after antiretroviral therapy suppression in a macaque RT-SHIV model Depletion of latent HIV-1 infection in vivo: a proof-of-concept study Viral and latent reservoir persistence in HIV-1-infected patients on therapy Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe HIV promoter integration site primarily modulates transcriptional burst size rather than frequency X4 tropic multi-drug resistant quasi-species detected at the time of primary HIV-1 infection remain exclusive or at least dominant far from PHI Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy An "escape clock" for estimating the turnover of SIV DNA in resting CD4⁺ T cells Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART.CpG methylation controls reactivation of HIV from latency.The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy.Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy.Measuring reversal of HIV-1 latency ex vivo using cells from infected individuals Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy.Semen-specific genetic characteristics of human immunodeficiency virus type 1 env.In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA.A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients.Combinatorial latency reactivation for HIV-1 subtypes and variants Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment.Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.Rapid turnover of 2-LTR HIV-1 DNA during early stage of highly active antiretroviral therapy.Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy.Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies Highly precise measurement of HIV DNA by droplet digital PCR.Pharmaceutical approaches to eradication of persistent HIV infection.Measuring turnover of SIV DNA in resting CD4+ T cells using pyrosequencing: implications for the timing of HIV eradication therapies Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations Generation of HIV latency in humanized BLT mice.

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P2860

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence

http://www.wikidata.org/entity/Q34960856

description

2003 nî lūn-bûn

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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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type

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Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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prefLabel

Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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Heterogeneous clearance rates ...... predicts lifelong persistence

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Proceedings of the National Academy of Sciences of the United States of America

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Heterogeneous clearance rates ...... predicts lifelong persistence

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C A Spina

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C C Ignacio

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D D Richman

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D V Havlir

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H Levine

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J K Wong

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L Bacheler

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M Fischer

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M Opravil

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P2860

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

The challenge of viral reservoirs in HIV-1 infection

Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

Viral dynamics in human immunodeficiency virus type 1 infection

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

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4819-4824

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Huldrych F Günthard

Andrew J Leigh Brown

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10813712

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