Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge
about
Expression library immunization to discover and improve vaccine antigens.Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challengeAnaplasma marginale type IV secretion system proteins VirB2, VirB7, VirB11, and VirD4 are immunogenic components of a protective bacterial membrane vaccine.Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sortingComparison of multiple DNA vaccines for protection against cytomegalovirus infection in BALB/c mice.Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replicationSalivary glands act as mucosal inductive sites via the formation of ectopic germinal centers after site-restricted MCMV infectionImmunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaques.DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.Preliminary evidence that the novel host-derived immunostimulant EP67 can act as a mucosal adjuvant.A focused salivary gland infection with attenuated MCMV: an animal model with prevention of pathology associated with systemic MCMV infection.Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization.Developing a Vaccine against Congenital Cytomegalovirus (CMV) Infection: What Have We Learned from Animal Models? Where Should We Go Next?Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.Vaccination of mice with bacteria carrying a cloned herpesvirus genome reconstituted in vivo.Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation.
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Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge
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2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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Strong CD8 T-cell responses fo ...... nst subsequent viral challenge
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Strong CD8 T-cell responses fo ...... nst subsequent viral challenge
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Strong CD8 T-cell responses fo ...... nst subsequent viral challenge
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P2860
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Strong CD8 T-cell responses fo ...... nst subsequent viral challenge
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Christopher S Morello
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10.1128/JVI.76.5.2100-2112.2002
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2002-03-01T00:00:00Z