Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. - Wikidata - awgldk - TriplyDB

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

http://www.wikidata.org/entity/Q34973847

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Intrinsic Hippocampal Excitability Changes of Opposite Signs and Different Origins in CA1 and CA3 Pyramidal Neurons Underlie Aging-Related Cognitive Deficits FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Channelopathy pathogenesis in autism spectrum disorders Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.Role of regucalcin in brain calcium signaling: involvement in aging.The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases Ryanodine receptors: physiological function and deregulation in Alzheimer disease.The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.mTOR in Brain Physiology and Pathologies.Calcium, Reactive Oxygen Species, and Synaptic Plasticity.Neuronal Ryanodine Receptors in Development and Aging.Propagation of Intracellular Ca2+ Signals in Aged Exocrine Cells.FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats.Novel calcium-related targets of insulin in hippocampal neurons.

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P2860

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

http://www.wikidata.org/entity/Q34973847

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

Disrupting function of FK506-b ...... notype in hippocampal neurons.

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

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type

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

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prefLabel

Disrupting function of FK506-b ...... notype in hippocampal neurons.

@ast

Disrupting function of FK506-b ...... notype in hippocampal neurons.

@en

Disrupting function of FK506-b ...... notype in hippocampal neurons.

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JNEUROSCI.4805-10.2011

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Journal of Neuroscience

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Disrupting function of FK506-b ...... notype in hippocampal neurons.

@en

P2093

Christopher M Norris

http://www.w3.org/2001/XMLSchema#string

Eric M Blalock

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Inga Kadish

http://www.w3.org/2001/XMLSchema#string

John C Gant

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Kuey-Chu Chen

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Nada M Porter

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Olivier Thibault

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Philip W Landfield

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P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

Elementary and global aspects of calcium signalling

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Functional differentiation in the hippocampus

Regionally selective alterations in expression of the alpha(1D) subunit (Ca(v)1.3) of L-type calcium channels in the hippocampus of aged rats

Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels.

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats.

Chaperone domains convert prolyl isomerases into generic catalysts of protein folding.

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10.1523/JNEUROSCI.4805-10.2011

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21289178

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