Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.
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Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceAcute mTOR inhibition induces insulin resistance and alters substrate utilization in vivomTOR signaling for biological control and cancer.Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.Rapamycin-induced metabolic defects are reversible in both lean and obese miceBeneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.Rapamycin impairs HPD-induced beneficial effects on glucose homeostasis.Koschei the immortal and anti-aging drugsMetabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on OutcomesRapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibitionAdjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease.Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.A Central role for mTOR in lipid homeostasis.Rapamycin-resistant effector T-cell therapy.Regulation of autophagy by amino acids and MTOR-dependent signal transduction.Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition.Potential therapeutic effects of mTOR inhibition in atherosclerosis.Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium.Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation.mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells.PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.Postexercise whole body heat stress additively enhances endurance training-induced mitochondrial adaptations in mouse skeletal muscle.
P2860
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P2860
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
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name
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@ast
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@en
type
label
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@ast
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@en
prefLabel
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@ast
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@en
P2093
P2860
P356
P1476
Rapamycin has a biphasic effec ...... sruption of mTORC1 and mTORC2.
@en
P2093
Behzad Varamini
David M Sabatini
Dudley W Lamming
Joseph A Baur
P2860
P356
10.3389/FGENE.2012.00177
P577
2012-09-11T00:00:00Z