Update on fetal hemoglobin gene regulation in hemoglobinopathies - Wikidata - awgldk - TriplyDB

Update on fetal hemoglobin gene regulation in hemoglobinopathies

Update on fetal hemoglobin gene regulation in hemoglobinopathies

http://www.wikidata.org/entity/Q34973945

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Genomic approaches to identifying targets for treating β hemoglobinopathies From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches Pregnancy in women with thalassemia: challenges and solutions Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.Molecular mechanism of yisui shengxue granule, a complex chinese medicine, on thalassemia patients suffering from hemolysis and anemia of erythrocytes Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.Nuclease-mediated gene editing by homologous recombination of the human globin locus.Fetal hemoglobin in sickle cell anemia A functional element necessary for fetal hemoglobin silencing Fetal hemoglobin levels in African American and Hispanic children with sickle cell disease at baseline and in response to hydroxyurea.β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.The multifunctional role of EKLF/KLF1 during erythropoiesis.Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity.Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde.Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells.Functional footprinting of regulatory DNA.Involvement of miRNA in erythroid differentiation.Skeletal muscle α-actin diseases (actinopathies): pathology and mechanisms.EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.Emerging science of hydroxyurea therapy for pediatric sickle cell disease.The Influence of Polymorphisms in Disease Severity in β-Thalassemia.Clinical phenotypes and the biological parameters of Congolese patients suffering from sickle cell anemia: A first report from Central Africa.Evaluation of the Effect of miR-26b Up-Regulation on HbF Expression in Erythroleukemic K-562 Cell Line Molecular basis of β thalassemia and potential therapeutic targets.Novel "omics" approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta.Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice.Inducing indel mutation in the SOX6 Gene by Zinc Finger Nuclease for gamma reactivation: An Approach towards Gene Therapy of Beta Thalassemia.G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.Polymorphism in the HMOX1 gene is associated with high levels of fetal hemoglobin in Brazilian patients with sickle cell anemia.Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.Genome Editing of Erythroid Cell Culture Model Systems.

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Update on fetal hemoglobin gene regulation in hemoglobinopathies

http://www.wikidata.org/entity/Q34973945

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年学术文章

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2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@ast

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@en

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@nl

type

label

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@ast

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@en

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@nl

prefLabel

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@ast

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@en

Update on fetal hemoglobin gene regulation in hemoglobinopathies

@nl

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Current Opinion in Pediatrics

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Update on fetal hemoglobin gene regulation in hemoglobinopathies

@en

P2093

Daniel E Bauer

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Stuart H Orkin

http://www.w3.org/2001/XMLSchema#string

P2860

Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo

EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

A global role for EKLF in definitive and primitive erythropoiesis

Sox6 directly silences epsilon globin expression in definitive erythropoiesis.

Looping and interaction between hypersensitive sites in the active beta-globin locus

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1-8

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scholarly article

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