The yjeQ gene is required for virulence of Staphylococcus aureus
about
Structural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopyCryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factorIsolation and characterization of biofilm formation-defective mutants of Staphylococcus aureusGenetic interaction screens with ordered overexpression and deletion clone sets implicate the Escherichia coli GTPase YjeQ in late ribosome biogenesis.RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.Staphylococcus aureus and Escherichia coli have disparate dependences on KsgA for growth and ribosome biogenesis.RsgA releases RbfA from 30S ribosome during a late stage of ribosome biosynthesis.The C-terminal helix in the YjeQ zinc-finger domain catalyzes the release of RbfA during 30S ribosome subunit assemblyppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteriaEscherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement.Chemical inhibition of bacterial ribosome biogenesis shows efficacy in a worm infection model.
P2860
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P2860
The yjeQ gene is required for virulence of Staphylococcus aureus
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The yjeQ gene is required for virulence of Staphylococcus aureus
@ast
The yjeQ gene is required for virulence of Staphylococcus aureus
@en
The yjeQ gene is required for virulence of Staphylococcus aureus
@nl
type
label
The yjeQ gene is required for virulence of Staphylococcus aureus
@ast
The yjeQ gene is required for virulence of Staphylococcus aureus
@en
The yjeQ gene is required for virulence of Staphylococcus aureus
@nl
prefLabel
The yjeQ gene is required for virulence of Staphylococcus aureus
@ast
The yjeQ gene is required for virulence of Staphylococcus aureus
@en
The yjeQ gene is required for virulence of Staphylococcus aureus
@nl
P2093
P2860
P356
P1476
The yjeQ gene is required for virulence of Staphylococcus aureus
@en
P2093
Eric D Brown
James Henderson
Tracey L Campbell
P2860
P304
P356
10.1128/IAI.00258-06
P407
P577
2006-08-01T00:00:00Z