Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
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Dynamics connect substrate recognition to catalysis in protein kinase AA Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPStructures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengersThe auto-inhibitory role of the EPAC hinge helix as mapped by NMRSignaling through dynamic linkers as revealed by PKARecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMRActive site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.The future of EPAC-targeted therapies: agonism versus antagonismBiochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Mapping allostery through the covariance analysis of NMR chemical shiftsDynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation.The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation FactorsStructure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Role of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A.Allosteric linkers in cAMP signalling.Using NMR to study fast dynamics in proteins: methods and applications.NMR reveals novel mechanisms of protein activity regulation.cAMP-dependent allostery and dynamics in Epac: an NMR view.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.A tool set to map allosteric networks through the NMR chemical shift covariance analysis.Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeabilityDiscerning intersecting fusion-activation pathways in the Nipah virus using machine learning.Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardiaProbing slow protein dynamics by adiabatic R(1rho) and R(2rho) NMR experimentsCrystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
P2860
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P2860
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@ast
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@en
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@nl
type
label
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@ast
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@en
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@nl
prefLabel
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@ast
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@en
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@nl
P2860
P50
P356
P1476
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
@en
P2093
Giuseppe Melacini
Soumita Sildas
P2860
P304
23682-23696
P356
10.1074/JBC.M109.011700
P407
P577
2009-04-29T00:00:00Z