Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. - Wikidata - awgldk - TriplyDB

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

http://www.wikidata.org/entity/Q34985463

about

Role of Sphingolipids in the Pathobiology of Lung Inflammation Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.Plasma sphingomyelin and longitudinal change in percent emphysema on CT. The MESA lung study Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts Allosteric modulation of beta1 integrin function induces lung tissue repair Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress.Vam3, a resveratrol dimer, inhibits cigarette smoke-induced cell apoptosis in lungs by improving mitochondrial function.EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke.Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration.Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury.Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema Lung cancer and lung injury: the dual role of ceramide Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines.Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium Involvement of ceramide in cell death responses in the pulmonary circulation.Pathogenesis of chronic obstructive pulmonary disease Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung.Second hand smoke and COPD: lessons from animal studies.ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction Plasma sphingolipids and lung cancer: a population-based, nested case-control study.Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.The role of sphingolipids in respiratory disease.Sphingolipid metabolism and neutral sphingomyelinases.Sphingolipids in the DNA damage response.Single-Photon Emission Computed Tomography/Computed Tomography Imaging in a Rabbit Model of Emphysema Reveals Ongoing Apoptosis In Vivo.Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia.The role of sphingolipids in psychoactive drug use and addiction.

P2860

Q26771956-65907B8E-FC86-4F1A-BBCF-FF3C22B8C548 Q27022944-B3AEDA34-2181-4D81-98D2-E12460E18266 Q27339695-3E2D4AFB-DD0A-47BB-AC34-2878057BB4E3 Q28389768-7B6A9BB3-C057-4DF9-9E1B-DD4A6050CA3F Q28544815-3602B0A0-F2F5-42E5-8B29-C910001EB662 Q30509545-0AD91464-26A5-4CE1-BB17-5E13D388B676 Q33715502-66AE0299-A38F-4B93-B2BC-80C85FB5ADB4 Q33756670-43FEA052-3186-4EEA-8AAD-E590E1ECCB7F Q33861903-C61542AC-5855-4A1B-9FCE-ABF278E9E3D1 Q33996985-C14C1544-8D4E-4FCC-8032-8D73DB77BEBE Q34104798-F3B223DA-83F0-4EBF-9EC5-3B82B70DC0C1 Q34432733-3F2ED982-FAB4-492D-A762-D3567CA01101 Q34586907-5C003129-4705-4589-A403-37F5FAFB41B5 Q35024497-DCD5D2DF-D3F3-4AEB-AF43-103A8D539537 Q35057070-2E60F673-6B34-4638-B5D6-B77DFC4204DF Q35083187-11665F80-8B1F-4CFC-9419-D5F337026E1C Q35207787-240075F3-2453-444F-A323-0FD707C3DC85 Q35643759-CEF21747-C554-4366-96EA-39090DF0E51F Q35814901-D9526941-E1C3-4155-82EF-E817AAF9EF6E Q35816405-A260F4E9-9326-4851-BAE9-0EF5C178758C Q35983863-F7593D4F-6A9D-4DB7-8B7E-E04C4DC37BC8 Q36129048-8AC07845-67B3-4B55-803F-FFF21A558DA5 Q36357042-96BA6F52-BDC8-45CA-BE94-0415E7AF1C33 Q36640817-197CBF48-2AC4-4EB1-AA3B-5A42FA2D2C2D Q36843326-78D02616-36DC-4970-AE39-F2C2D3904F01 Q37005492-4C4726F7-A53D-4D4F-AE6B-F68EF2B79893 Q37069137-A8DAA88B-619A-4D28-8EE3-98FE033E1E7C Q37248481-DBC06849-3A20-4050-9486-44469BD715FF Q37880161-3A2EE848-0038-468F-BA1E-913C8AD73BF2 Q37928817-9BFCF9E3-0D30-4856-9784-ED97398EDDF9 Q38098404-60FA3791-E7BF-401B-AF64-F0E2B64E085E Q38272799-75758651-E6E4-454F-AB38-2A5D8632B256 Q38835337-B3693B89-2980-4EBD-9188-F3ED82BA4DE4 Q48275464-C06CC4A8-7217-43BC-9DB7-7C6210673EB6 Q50098238-71706F16-2A18-41B1-983D-972EC0BDB676

P2860

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

http://www.wikidata.org/entity/Q34985463

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@ast

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@en

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@nl

type

label

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@ast

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@en

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@nl

prefLabel

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@ast

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@en

Neutral sphingomyelinase 2: a ...... ced apoptosis and lung injury.

@nl

P1433

Q34985463-855524DF-B3DA-4BB5-A45C-B55ED1D6C70D

P1476

Q34985463-278C30D3-BA91-408B-876B-194DFC6E29F6

P2093

Q34985463-11415B92-8E17-40B1-94B4-749D2CC0234F

Q34985463-2CD9FB97-272B-4931-B56E-55C2C4AEB9A1

Q34985463-4F9B2FA7-51EA-45F7-8578-B4E032004ADA

Q34985463-8F6EBF65-6B33-4B81-ADC0-A8EBC09159D0

Q34985463-8FF0D533-A6D9-4423-9E6D-6E58872C3450

Q34985463-9CA2C067-A2EF-4033-81EA-6EDCE04BF915

Q34985463-AE47519C-F63E-4B50-9DCB-FD3CB4BF544E

Q34985463-E96B6BC9-A5C2-4E5F-9DA8-1DC1BA8847D8

Q34985463-ED19C230-7069-44D6-9DB7-AA0A4CCE6F97

P2860

Q34985463-00A91922-C82F-4C46-BDFE-DE682FD44EC2

Q34985463-010CD65C-BBA6-45A5-A62B-73E385770157

Q34985463-0A0D7186-626E-448D-B600-F0022BB59802

Q34985463-0A81C673-CFF6-4EA0-B96F-8CFFD08FE5F3

Q34985463-0CA4C036-4F80-4331-9B69-EADDB3CBD795

Q34985463-0E215C19-5150-4BF3-A2C2-99758263D587

Q34985463-15F970A5-FCE3-4385-9A7F-2A28D2EE23E0

Q34985463-18276C90-8EAA-4A24-93D1-1BFA7F7464D3

Q34985463-1A12F600-AECD-46F0-8F4C-71A687A9C2DC

Q34985463-373DBFC5-BC7A-42A1-A81D-733082D75F07

P304

Q34985463-C9B167B4-3544-4A6C-8D79-192DC07FEA52

P31

Q34985463-5054BFB0-5BD4-4A39-A100-370DA45FE4A7

P356

Q34985463-3AD35A0E-CD24-4240-B8EA-25B444567A4D

P433

Q34985463-FE0C894C-9679-446D-B219-9C10A3BE82CA

P478

Q34985463-7D24E16A-9854-4403-B480-CD807F546B9C

P50

Q34985463-D102D9AF-FE8A-4827-8FFF-20DBEE982002

P577

Q34985463-E23EC179-7E89-4236-B184-7B664AAE93A4

P5875

Q34985463-75C9A55B-7A72-4332-AB06-4B91C5B3F79D

P698

Q34985463-49B48BCA-9B53-4A41-8FD2-2A7D74BE8816

P921

Q34985463-46D11AAB-B77F-41FD-87DD-5283B887B198

P932

Q34985463-8FFE81BA-F2AB-4351-8A6D-DD7797DCA184

P356

RCMB.2009-0422OC

P1433

American Journal of Respiratory Cell and Molecular Biology

P1476

Neutral sphingomyelinase 2: a ...... uced apoptosis and lung injury

@en

P2093

Aaron Danielson

http://www.w3.org/2001/XMLSchema#string

Elaine Khan

http://www.w3.org/2001/XMLSchema#string

Jerold Last

http://www.w3.org/2001/XMLSchema#string

Kent Pinkerton

http://www.w3.org/2001/XMLSchema#string

Lisa Franzi

http://www.w3.org/2001/XMLSchema#string

Nick Kenyon

http://www.w3.org/2001/XMLSchema#string

Rubin Tuder

http://www.w3.org/2001/XMLSchema#string

Sianna Castillo

http://www.w3.org/2001/XMLSchema#string

Tzipora Goldkorn

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)

Models of chronic obstructive pulmonary disease

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione

Animal models of chronic obstructive pulmonary disease

Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation

Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling.

Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis.

P304

350-360

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1165/RCMB.2009-0422OC

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

44

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-05-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

44578483

http://www.w3.org/2001/XMLSchema#string

P698

20448054

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

3095936

http://www.w3.org/2001/XMLSchema#string