Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
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Mechanisms of acupuncture-electroacupuncture on persistent painmTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesiaTranslational control of nociception via 4E-binding protein 1Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesiaAdenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory painA novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery.mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain.mTOR kinase: a possible pharmacological target in the management of chronic pain.Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal hornSpinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitisMammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromesSinularin from indigenous soft coral attenuates nociceptive responses and spinal neuroinflammation in carrageenan-induced inflammatory rat model.Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in RatmTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injuryProtein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons.Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat.Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and AktIntact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury.Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator.Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis.Endogenous PI3K/Akt and NMDAR act independently in the regulation of CREB activity in lumbosacral spinal cord in cystitis.Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury.Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.Drug repositioning: playing dirty to kill pain.Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.Neuropeptide substance P and the immune response.Targeting AMPK for the Alleviation of Pathological Pain.Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.mTOR and Erk1/2 Signaling in the Cerebrospinal Fluid-Contacting Nucleus is Involved in Neuropathic Pain.Homers at the Interface between Reward and Pain.Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitizationRegulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity.
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P2860
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@ast
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@en
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@nl
type
label
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@ast
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@en
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@nl
prefLabel
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@ast
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@en
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@nl
P2093
P2860
P1476
Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia
@en
P2093
Audrey O'Neill
Bethany Fitzsimmons
Joanne Steinauer
Qinghao Xu
Tony L Yaksh
Xiao-Ying Hua
P2860
P304
P356
10.1523/JNEUROSCI.2139-10.2011
P407
P577
2011-02-01T00:00:00Z