Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia - Wikidata - awgldk - TriplyDB

Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia

Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia

http://www.wikidata.org/entity/Q34989480

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Mechanisms of acupuncture-electroacupuncture on persistent pain mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia Translational control of nociception via 4E-binding protein 1 Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery.mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain.mTOR kinase: a possible pharmacological target in the management of chronic pain.Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes Sinularin from indigenous soft coral attenuates nociceptive responses and spinal neuroinflammation in carrageenan-induced inflammatory rat model.Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons.Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat.Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury.Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator.Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis.Endogenous PI3K/Akt and NMDAR act independently in the regulation of CREB activity in lumbosacral spinal cord in cystitis.Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury.Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.Drug repositioning: playing dirty to kill pain.Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.Neuropeptide substance P and the immune response.Targeting AMPK for the Alleviation of Pathological Pain.Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.mTOR and Erk1/2 Signaling in the Cerebrospinal Fluid-Contacting Nucleus is Involved in Neuropathic Pain.Homers at the Interface between Reward and Pain.Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization Regulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity.

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Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia

http://www.wikidata.org/entity/Q34989480

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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JNEUROSCI.2139-10.2011

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Journal of Neuroscience

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Spinal phosphinositide 3-kinas ...... lammation-induced hyperalgesia

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Audrey O'Neill

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Bethany Fitzsimmons

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Joanne Steinauer

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Qinghao Xu

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Tony L Yaksh

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Xiao-Ying Hua

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P2860

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

mTOR signaling: at the crossroads of plasticity, memory and disease

The selectivity of protein kinase inhibitors: a further update

A complex interplay between Akt, TSC2 and the two mTOR complexes

Molecular mechanisms of mTOR-mediated translational control

Quantitative assessment of tactile allodynia in the rat paw

The nuts and bolts of AGC protein kinases

Regulation of cap-dependent translation by eIF4E inhibitory proteins

Local translation in primary afferent fibers regulates nociception

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

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10.1523/JNEUROSCI.2139-10.2011

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Alexandra C. Newton

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21307248

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