DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.
about
Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayThe Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR SpectroscopyElucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.Theoretical studies on FGFR isoform selectivity of FGFR1/FGFR4 inhibitors by molecular dynamics simulations and free energy calculations.Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.Biophysical characterization of drug-resistant mutants of fibroblast growth factor receptor 1.Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.
P2860
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P2860
DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@ast
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@en
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@nl
type
label
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@ast
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@en
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@nl
prefLabel
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@ast
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@en
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@nl
P2093
P2860
P50
P356
P1433
P1476
DFG-out mode of inhibition by ...... er mutations in FGF receptors.
@en
P2093
Huiyan Wang
Jingjing Deng
Nathanael S Gray
Steven Blais
Xiaokun Li
Zhifeng Huang
P2860
P304
P356
10.1021/CB500674S
P577
2014-10-27T00:00:00Z